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  4. Recombinant Mouse PDZ and LIM domain protein 7 (Pdlim7)

Recombinant Mouse PDZ and LIM domain protein 7 (Pdlim7)

  • 中文名称：
    小鼠Pdlim7重组蛋白
  • 货号：
    CSB-YP661008MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pdlim7重组蛋白
  • 货号：
    CSB-EP661008MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pdlim7重组蛋白
  • 货号：
    CSB-EP661008MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pdlim7重组蛋白
  • 货号：
    CSB-BP661008MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pdlim7重组蛋白
  • 货号：
    CSB-MP661008MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pdlim7
  • Uniprot No.：
  • 别名：
    Pdlim7; Enigma; PDZ and LIM domain protein 7; LIM mineralization protein; LMP; Protein enigma
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-457
  • 氨基酸序列
    MDSFKVVLEG PAPWGFRLQG GKDFNVPLSI SRLTPGGKAA QAGVAVGDWV LNIDGENAGS LTHIEAQNKI RACGERLSLG LSRAQPVQSK PQKALTPPAD PPRYTFAPSA SLNKTARPFG APPPTDSTLR QNGQLLRQPV PDASKQRLME DTEDWRPRPG TGQSRSFRIL AHLTGTEFMQ DPDEEFMKKS SQVPRTEAPA PASTIPQESW PGPTTPSPTS RPPWAVDPAF AERYAPDKTS TVLTRHSQPA TPTPLQNRTS IVQAAAGGGT GGGSNNGKTP VCHQCHKIIR GRYLVALGHA YHPEEFVCSQ CGKVLEEGGF FEEKGAIFCP SCYDVRYAPN CAKCKKKITG EIMHALKMTW HVHCFTCAAC KTPIRNRAFY MEEGAPYCER DYEKMFGTKC RGCDFKIDAG DRFLEALGFS WHDTCFVCAI CQINLEGKTF YSKKDKPLCK SHAFSHV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway.
  • 基因功能参考文献：
    1. primary endogenous regulator of platelet-dependent hemostasis PMID: 27792740
    2. PDLIM7 is a bona fide skeletal muscle substrate of Nedd4-1. PMID: 26556890
    3. findings describe a positive regulatory effect of LMP-1 on BMP-2 expression and BMP-2-mediated osteogenesis. This effect occurs through activation of ERK1/2 pathway and subsequent upregulation of Runx2 transactivity. PMID: 25677945
    4. LMP is an important determinant of weight and length, female bone density, and marrow stromal cell propensity for mineralization. PMID: 25032549
    5. These findings reveal a novel and unexpected function for Pdlim7 in maintaining proper hemostasis in neonatal and adult mice. PMID: 24278323
    6. LMP-1 showed spatiotemporal expression patterns during molar development.[LMP-1] PMID: 20706776

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 数据库链接：

    KEGG: mmu:67399

    STRING: 10090.ENSMUSP00000047173

    UniGene: Mm.275648