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  4. Recombinant Mouse PR domain zinc finger protein 5 (Prdm5)

Recombinant Mouse PR domain zinc finger protein 5 (Prdm5)

  • 中文名称：
    小鼠Prdm5重组蛋白
  • 货号：
    CSB-YP875151MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Prdm5重组蛋白
  • 货号：
    CSB-EP875151MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Prdm5重组蛋白
  • 货号：
    CSB-EP875151MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Prdm5重组蛋白
  • 货号：
    CSB-BP875151MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Prdm5重组蛋白
  • 货号：
    CSB-MP875151MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Prdm5
  • Uniprot No.：
  • 别名：
    Prdm5; PR domain zinc finger protein 5; EC 2.1.1.-; PR domain-containing protein 5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-599
  • 氨基酸序列
    MLGMYVPDRF ALKSSRVQDG MGLYTARRVR KGEKFGPFAG EKRMPEDLDE NMDYRLMWEV RGSKGEVLYI LDATNPRHSN WLRFVHEAPS QERKNLAAIQ EGENIFYLAV DDIETDTELL IGYLDSDVEA EEEEQQALTM TKEGKVDHSK GQLAAGSKGH LGCEEDFACP QCESSFPSEE VLTEHLQSLH QKPTGEKEFK CENCGKKFPV RQALQRHFEQ HRKACRGEAR FVCKADSCGK RLKSKDALRR HQENVHTGDP KRKLICSVCN RKCTSVSSLQ EHRKIHEIFD CQECMKKFIS ANQLKRHMIT HSEKRPYNCE ICNKSFKRLD QVGAHKVIHS EDKPYQCKLC GKGFAHRNVY KNHKKTHSEE RPFQCDACKA LFRTPFSLQR HLLIHNSERT FKCHHCDATF KRKDTLNVHV QVVHERHKKY RCELCNKAFV TPSVLRSHKK THTGEKEKVC PYCGQKFASS GTLRVHIRSH TGERPYQCPY CEKGFSKNDG LKMHIRTHTR EKPYQCSECS KAFSQKRGLD EHKRTHTGEK PFQCDVCDLA FSLKKMLIRH KMTHNPNRPM AECHFCHKKF TRNDYLKVHM DNIHGVADS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, connective tissue components and molecules regulating cell migration and adhesion. May cause G2/M arrest and apoptosis in cancer cells.
  • 基因功能参考文献：
    1. PRDM5 promotes the proliferation and invasion of murine melanoma cells through up-regulating JNK expression and strategies targeting PRDM5 may be promising for the therapy of melanoma. PMID: 27485778
    2. Data provide the first causal link between Prdm5 loss and intestinal carcinogenesis, and uncover an extensive and novel PRDM5 target repertoire likely facilitating the tumor-suppressive functions of PRDM5. PMID: 23873026
    3. These data indicate how Prdm5 modulates transcription by interacting with factors involved in genome organization in mouse embryonic stem cells. PMID: 24043305
    4. we show that Prdm5 controls both Collagen I transcription and fibrillogenesis by binding inside the Col1a1 gene body and maintaining RNA polymerase II occupancy PMID: 22589746
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 数据库链接：

    KEGG: mmu:70779

    STRING: 10090.ENSMUSP00000031976

    UniGene: Mm.263355