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  4. Recombinant Mouse PR domain zinc finger protein 8 (Prdm8)

Recombinant Mouse PR domain zinc finger protein 8 (Prdm8)

  • 货号：
    CSB-YP803967MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP803967MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP803967MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP803967MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP803967MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Prdm8
  • Uniprot No.：
  • 别名：
    Prdm8; PR domain zinc finger protein 8; EC 2.1.1.-; PR domain-containing protein 8
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-687
  • 氨基酸序列
    MEDSGIQRGI WDGDAKAVQQ CLTDIFTSVY TTCDIPENAI FGPCVLSHTS LYDSIAFVAL KSTDKRTVPY IFRVDTSAAN GSSEGLMWLR LVQSARDKEE QNLEAYIKNG QLFYRSLRRI AKDEELLVWY GKELTELLLL CPSRAHKMNG SSPYTCLECS QRFQFEFPYV AHLRFRCPKR LHSTDANPQD EQGGGLGTKD HGGGGGGKEQ QQQQQQQQQE APLIPGPKFC KAGPIHHYPA SSPEASNPPG SAGASSAKPS TDFHNLAREL ENSRGNSSCV AAPGVGSGGS GHQEAELSPD GVATGGCKGK RRFPEEAAAE GGGAGLAGGR ARFSERPLAT SKEELVCTPQ QYRAAGSYFG LEENGRLFAP PSPETGEAKR SAFVEVKKAG RAVGLQEEAA ATDGAGGTAE DPDAGGGVAG GGSNGSSTPA AGSPGAPEKL LAPRPGGSLP GRLEGGSPAR GSAFTSVSQL GGGGGAGTAG TAGGSGGGQT AASDERKSAF SQPARSFSQL SPLVLGQKLG ALEPCHPGDG VGPTRLYPAA ADPLAVKLQG AADLNGACGP LASGGGGGLP KQSPFLYATA FWPKSSAAAA AAAAAAAGPL QLQLPSALTL LPPSFTSLCL PAQNWCAKCN ASFRMTSDLV YHMRSHHKKE YAMEPLVKAA AGGETQVPHL QRVLQGASPP VPAHDLA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3. Histone methyltransferase activity has not been confirmed in other species. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR. Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival.
  • 基因功能参考文献：
    1. Our findings highlight the critical role of Ebf3 in multipolar-to-bipolar transition via positive feedback regulation of NeuroD1 in the developing neocortex. PMID: 29113800
    2. findings establish that PRDM8 is required for RB and type 2 OFF-CB cell survival and amacrine subtype identity, and they present PRDM8 as a candidate gene for human CSNB PMID: 26023183
    3. Prdm8 regulates the morphological transition at multipolar phase during neocortical development. PMID: 24489718
    4. These findings suggest that Prdm8 is an obligate partner of Bhlhb5, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of Cadherin-11. PMID: 22284184
    5. These results show that Prdm8 expression is tightly regulated in a spatio-temporal manner during neural development and mainly restricted to postmitotic neurons, except in the spinal cord. PMID: 19616129
    6. PRDM8 repressed the expression of steroidogenic markers, p450c17c and LHR, which indicates its regulatory role in mouse testis development. PMID: 19646955

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 组织特异性：
    Expressed in brain, heart, liver, testes, retina. Highest expression is observed in the retina and hippocampus; moderately expressed in the cortex and cerebellum. In the retina, it is expressed in bipolar and amacrine cells.
  • 数据库链接：

    KEGG: mmu:77630

    STRING: 10090.ENSMUSP00000108583

    UniGene: Mm.332511