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  4. Recombinant Mouse PRKC apoptosis WT1 regulator protein (Pawr)

Recombinant Mouse PRKC apoptosis WT1 regulator protein (Pawr)

  • 货号：
    CSB-YP849765MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP849765MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP849765MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP849765MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP849765MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Pawr; Par4; PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 protein; Par-4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-333
  • 氨基酸序列
    MATGGYRSGG STTTDFLEEW KAKREKMRAK QNPAGPGSSG GDPAAKSPAG SLTPTAVAGT SELNHGPAGA AAPAAPAPGA LNCAHGSSTL PRAAPGSRRA EDECPSAAAA SGAPGSRGDE EEPDSAREKG RSSGPSARKG KGQIEKRKLR EKRRSTGVVN IPAAECLDEY EDDEAGQKER KREDAITQQN TIQNEAATLP DPGTSYLPQD PSRTVPGRYK STTSAPEDEI SNRYPRTDRS GFSRHNRDAN APASFSSSST LEKRIEDLEK EVVRERQENL RLVRLMQDKE EMIGKLKEEI DLLNRDLDDM EDENEQLKQE NKTLLKVVGQ LTR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
  • 基因功能参考文献：
    1. Induced by endoplasmic reticulum stress Par-4 acts as an important defense mechanism against mycobacterial infection and regulates cancer. PMID: 27552917
    2. Findings reveal a novel role for Par-4/NF-kappaB in islet beta cell apoptosis and type 2 diabetes. PMID: 27340675
    3. Par4, CEBPB and FAK form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT and self-renewal PMID: 25472717
    4. a novel mechanism of apoptosis induction by PAR-4/ceramide-enriched exosomes, which may critically contribute to Alzheimer disease. PMID: 22532571
    5. extracellular Par-4/SAC is systemically functional in inhibition of tumor growth and metastasis progression. PMID: 21613819
    6. loss of PAR4 leads to a reduction in the ability of tumour necrosis factor-alpha to induce apoptosis by increased activation of NF-kappaB PMID: 12634851
    7. Antisense knockdown of PAR-4 or inhibition of ceramide biosynthesis reduced stem cell apoptosis; PAR-4 overexpression and treatment with ceramide analogs elevated apoptosis. PMID: 12885759
    8. Regulates T cell proliferation and differentiation. PMID: 12970181
    9. AATF is an endogenous antagonist of Par-4 activity and an effective inhibitor of aberrant amyloid beta 1-42 production and secretion under apoptotic conditions. PMID: 14627703
    10. Par-4 is directly involved in regulating choline uptake by interacting with CHT1 and by reducing its incorporation on the cell surface PMID: 15090548
    11. the mechanism for Ras-mediated down-regulation of Par-4 is by promoter methylation PMID: 15831492
    12. direct physical association with ceramide and PAR-4 regulates the activity of PKCzeta PMID: 15901738
    13. Par-4 is identified as a regulatory component in dopamine signaling PMID: 16051151
    14. Determined the first SPRY-domain structure of SSB-2 that adopts a novel fold and contains conserved structural determinants for binding to prostate apoptosis response protein-4 (PAR-4). PMID: 16369487
    15. Results describe a novel isoform of prostate apoptosis response 4 (PAR-4) that co-distributes with F-actin and prevents apoptosis in neural stem cells. PMID: 16520897
    16. Par-4 is a novel and early mediator of renal tubule cell injury following ischemia-reperfusion-induced renal injury and provide a potential target for developing new therapeutic strategies for renal ischemia-reperfusion-induced renal injury PMID: 16896190
    17. examined calcium mobilization in platelets from mice that were wild-type or homozygous null for PAR-4 or P2Y1 receptors, hypothesizing that the loss of PAR-4 or P2Y1 receptors would cause redistribution of its Galphaq proteins to other receptors [PAR-4] PMID: 16973501
    18. The lack of Par-4 dramatically enhances Ras-induced lung carcinoma formation in vivo, acting as a negative regulator of Akt activation. PMID: 18650932
    19. cooperation between Par-4 and PTEN as relevant for the development of prostate cancer and implicate the NF-kappaB pathway as a critical event in prostate tumorigenesis. PMID: 19470463
    20. By 6 mo of age, glomerular disease was severe in Par4-/- mice. PMID: 19497968

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 数据库链接：

    KEGG: mmu:114774

    STRING: 10090.ENSMUSP00000092951

    UniGene: Mm.391419