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  4. Recombinant Mouse Paired immunoglobulin-like type 2 receptor alpha (Pilra), partial

Recombinant Mouse Paired immunoglobulin-like type 2 receptor alpha (Pilra), partial

  • 中文名称：
    小鼠Pilra重组蛋白
  • 货号：
    CSB-YP651335MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pilra重组蛋白
  • 货号：
    CSB-EP651335MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pilra重组蛋白
  • 货号：
    CSB-EP651335MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pilra重组蛋白
  • 货号：
    CSB-BP651335MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pilra重组蛋白
  • 货号：
    CSB-MP651335MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pilra
  • Uniprot No.：
  • 别名：
    Pilra; Paired immunoglobulin-like type 2 receptor alpha; Cell surface receptor FDF03; Inhibitory receptor PILR-alpha
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. Receptor for CD99 and PIANP.
  • 基因功能参考文献：
    1. Data suggest that immune inhibitory receptor, PILRalpha, plays an important role in the prevention of obesity and liver fibrosis. PMID: 26840635
    2. negatively regulates inflammatory colitis by reducing the neutrophil and macrophage infiltration PMID: 25710489
    3. demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilralpha is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation PMID: 26188512
    4. Data indicate paired Ig-like type 2 receptor (PILR)alpha Pilra-/- mice develop enhanced autoimmune arthritis. PMID: 24935926
    5. regulates neutrophil recruitment in inflammatory responses modulation of integrin activation PMID: 23142774
    6. Data show that PILRalpha/ligand interactions require conserved PILRalpha arginine (Arg)-133 (mouse) and Arg-126 (human). PMID: 22396535
    7. These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha. PMID: 21241660
    8. abilities of HSV-1 to enter cells in a PILRalpha-dependent manner and to acquire specific carbohydrates on gB are therefore linked to an increase in viral replication and virulence PMID: 20686018
    9. Domain V of paired Ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion. PMID: 20573830

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 数据库链接：

    KEGG: mmu:231805

    STRING: 10090.ENSMUSP00000050313

    UniGene: Mm.379385