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  4. Recombinant Mouse Parkin coregulated gene protein homolog (Pacrg)

Recombinant Mouse Parkin coregulated gene protein homolog (Pacrg)

  • 中文名称：
    小鼠Pacrg重组蛋白
  • 货号：
    CSB-YP863566MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pacrg重组蛋白
  • 货号：
    CSB-EP863566MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pacrg重组蛋白
  • 货号：
    CSB-EP863566MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pacrg重组蛋白
  • 货号：
    CSB-BP863566MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pacrg重组蛋白
  • 货号：
    CSB-MP863566MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pacrg
  • Uniprot No.：
  • 别名：
    Pacrg; Parkin coregulated gene protein homolog; Hypertension-related protein 1-like protein; PARK2 coregulated gene protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-241
  • 氨基酸序列
    MPKRTKLLPQ QTFQVHQPRS LVSEGFTVKA MMKNSVVRGP PVAGAFKERP AKPTTFRKCY ERGDFPIALE HDSKGNKIAW KVEIEKLDYH HYLPLFFDGL SEMTFPYEFF ARRGIHDMLE HGGNKILPVI PQLIIPIKNA LNLRNRQIIC VTLKVLQHLV VSSEMVGEAL LPYYRQILPI LNIFKNMNVN SGDGIDYSQQ KRENIGDLIQ ETLEAFERYG GEDAFINIKY MVPTYESCLL N
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited.
  • 基因功能参考文献：
    1. Studies demonstrate that MEIG1/PACRG forms a complex in the manchette and that this complex is necessary to transport cargos, such as SPAG16L, to build the sperm flagella. PMID: 25715396
    2. Pacrg is required for motile cilia function and may be involved in the pathogenesis of hydrocephalus. PMID: 20106870
    3. Findings reveal a critical role for the MEIG1/PARCG partnership in manchette structure and function and the control of spermiogenesis. PMID: 19805151
    4. PACRG is linked to parkin via a bi-directional promoter [PACRG] PMID: 12547187
    5. The quaking mutation is a deletion of approximately 1.17 Mb of mouse chromosome 17, resulting in the deletion of the entire promoter and first five coding exons of PRKN. The recently described Parkin Co-Regulated Gene (PACRG) is completely deleted. PMID: 14743368
    6. Results demonstrate that the deletion of Pacrg (PARKIN-coregulated gene) is the cause of male sterility in the Quaking(viable) (qk(v)) mutant mouse. PMID: 15148410
    7. These results suggest that the transcriptional co-regulation of Pacrg and parkin leads to a similar regional protein distribution in mouse brain, which may have functional significance for the two proteins. PMID: 18295750
    8. The results of this study indicated that expression of Pacrg in the cells associated with the cerebral ventricle, in addition to the aqueduct of Sylvius and choroid plexus. And strong expression was observed since newborn period to adulthood. PMID: 19463890
    9. Pacrg is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia. PMID: 17971504

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  • 数据库链接：

    KEGG: mmu:69310

    STRING: 10090.ENSMUSP00000044376

    UniGene: Mm.18889