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  4. Recombinant Mouse Pejvakin (Pjvk)

Recombinant Mouse Pejvakin (Pjvk)

  • 货号：
    CSB-YP611893MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP611893MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP611893MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP611893MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP611893MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pjvk
  • Uniprot No.：
  • 别名：
    Pjvk; Dfnb59; Gm1001; Pejvakin; Autosomal recessive deafness type 59 protein homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-352
  • 氨基酸序列
    MFAAATKSFV KQVGDGGRLV PVPSLSEADK YQPLSLVVKK KRCFLFPRCK FTSTPFTLKD ILLGDREISA GISSYQLLNY EDESDVSLYG RRSNHIVNDV GINVTGSDSI AVKASFGVVT KHEVEVSTLL KEITARKINF DHSLIRQSRS SRKAVLCVVM ESIRTTRQCS LSVHAGIRGE AMRFHFMDEQ NPKGREKAIV FPAHTTIAFS VFELFIYLDG AFDICVTSVS KGGFEREETT TFAMFYRLRN ILFERNRRVM DAISRSQLYL DDLFSDFYDK PLSMTDISLK EGTHIRVNLL NHNIPKGPCI LCGMGNLKRE TVYGCFQCSV DGVKYVRLHA VPCFDIWHKR MK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation.
  • 基因功能参考文献：
    1. Results demonstrate that pejvakin is required to sustain outer hair cell activity and survival in a cell-autonomous manner and imply pejvakin defects in sensory hearing loss rather than auditory neuropathy spectrum disorder; show that pejvakin forms protein complexes with Rho effectors, including ROCK2. PMID: 28089576
    2. Study describes a genetic form of noise-induced hearing loss , by showing that pejvakin deficiency in mice and DFNB59 patients leads to hypervulnerability to sound, due to a peroxisomal deficiency. PMID: 26544938
    3. The pejvakin allele described here introduces a premature stop codon, causes outer hair cell defects, and leads to progressive hearing loss. PMID: 17329413
  • 亚细胞定位：
    Peroxisome membrane. Cell projection, cilium.
  • 蛋白家族：
    Gasdermin family
  • 组织特异性：
    In ear, it is detected in the organ of Corti and the spiral ganglion within the cochlea in the sensory areas of the vestibule (cristae ampullares of the semicircular ducts, and maculae of the saccule and utricle) and in the first 3 relays (cochlear nuclei
  • 数据库链接：

    KEGG: mmu:381375

    STRING: 10090.ENSMUSP00000097566

    UniGene: Mm.330312