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  4. Recombinant Mouse Pentraxin-related protein PTX3 (Ptx3)

Recombinant Mouse Pentraxin-related protein PTX3 (Ptx3)

  • 中文名称：
    小鼠Ptx3重组蛋白
  • 货号：
    CSB-YP019079MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ptx3重组蛋白
  • 货号：
    CSB-EP019079MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ptx3重组蛋白
  • 货号：
    CSB-EP019079MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ptx3重组蛋白
  • 货号：
    CSB-BP019079MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ptx3重组蛋白
  • 货号：
    CSB-MP019079MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ptx3
  • Uniprot No.：
  • 别名：
    Ptx3; Tsg14; Pentraxin-related protein PTX3; Pentaxin-related protein PTX3; Tumor necrosis factor-inducible gene 14 protein; TSG-14
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-381
  • 氨基酸序列
    ETS DDYELMYVNL DNEIDNGLHP TEDPTPCDCR QEHSEWDKLF IMLENSQMRE GMLLQATDDV LRGELQRLRA ELGRLAGGMA RPCAAGGPAD ARLVRALEPL LQESRDASLR LARLEDAEAR RPEATVPGLG AVLEELRRTR ADLSAVQSWV ARHWLPAGCE TAIFFPMRSK KIFGSVHPVR PMKLESFSTC IWVKATDVLN KTILFSYGTK WNPYEIQLYL SSQSLVLVVG GKENKLAADT VVSLGRWSHL CGTWSSEQGS MSLWANGELV ATTVEMAKSH SVPEGGLLQI GQEKNGCCVG GGFDESLAFS GRITGFNIWD RVLSEEEIRA SGGVESCHIR GNVVGWGVTE IQAHGGAQYV S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
  • 基因功能参考文献：
    1. determined that PTX3 was an important moderator of obesity; inflammation during pregnancy could lead to a significant increase in the levels of the inflammatory factor PTX3. PMID: 28770376
    2. Alcoholic intoxication suppresses pentraxin 3 expression and contributes to exacerbation of sepsis. PMID: 28965650
    3. increased susceptibility to Aspergillus fumigatus correlates with downregulation of Ptx3 expression in calcineurin-deficient mice PMID: 27301880
    4. Pneumococcal toxin pneumolysin was responsible for PTX3 expression and upregulated PTX3 expression via JNK MAPK signaling. These data implicate PTX3 as a novel therapeutic target for the control of acute inflammation by pneumococcus. PMID: 28864415
    5. PTX3 may bridge the humoral arms of the innate and adaptive immune systems by serving as an endogenous adjuvant for marginal zone B cells. PMID: 27621420
    6. PTX3 levels increase in the airways of patients with severe asthma and OVA-exposed mice. Deletion of PTX3 results in enhanced inflammation, airway hyper-responsiveness, and mucus production on OVA sensitization and challenge.On OVA exposure, CD4 T cells from Ptx3-/- mice exhibit an enhanced survival in contrast to Ptx3+/+ mice PMID: 27567326
    7. PTX3 plays a non-redundant role in resistance against microbial pathogens and in the regulation of inflammation. (Review) PMID: 26650391
    8. PTX3 produced from bone marrow-derived cells plays a crucial role in cardiac protection. PMID: 26470821
    9. PTX3 expression is elevated in spinal cords during chronic relapsing EAE in Biozzi ABH mice, but the EAE severity and time course in PTX3-deficient mice did not differ from WT mice PMID: 26576501
    10. Cardioprotective function of immunoproteasome-dependent PTX3 expression revealed a crucial mechanism of the stress-induced damage response in myocardial inflammation. PMID: 26578407
    11. Deficiency of Long Pentraxin PTX3 Promoted Neointimal Hyperplasia after Vascular Injury. PMID: 25342475
    12. Neisseria meningitidis is recognized by PTX3, which serves as an endogenous adjuvant against meningococcal infection. PMID: 25786110
    13. These data suggest that the relative levels of SAP and PTX3 present at sites of fibrosis may have a significant effect on the ability of monocytes to differentiate into fibrocytes. PMID: 25774777
    14. our study identified a previously undescribed pathogenic role of PTX3 during virus infection PMID: 25695775
    15. PTX3 has a role in tissue remodeling and repair, involved in matrix and microbial recognition, which may be common, ancestral features of the humoral arm of innate immunity PMID: 25964372
    16. The host-protective effects of PTX3 in sepsis are a result of its coaggregation with histones rather than its ability to mediate pattern recognition. PMID: 25227610
    17. PTX3, an effector molecule belonging to the humoral arm of innate immunity, acts as an extrinsic oncosuppressor gene in mouse and man by regulating Complement-dependent, macrophage-sustained, tumor-promoting inflammation. PMID: 25679762
    18. Results suggests that miR-224 regulates Ptx3 under normal conditions. PMID: 24470395
    19. 10-fold-greater PTX3 levels were observed. PMID: 25001601
    20. The PTX3-driven increase in the osteoclastogenic potential of precursor osteoblasts (pOB) appears to be mediated by the effect of PTX3 on pOB RANKL production. PMID: 24664887
    21. miR-224 may affect ovulation and subsequent embryo development by targeting Ptx3. PMID: 24145127
    22. gene-deficient mice show defective control of urinary tract infection and exacerbated inflammation PMID: 24745336
    23. PTX3 expression induced by proinflammatory signals after ischemic brain injury is a critical effector of edema resolution and glial scar formation. PMID: 24346689
    24. The decrease in PTX3 protein in the adipose tissue and skeletal muscles may partly contribute to obesity-induced insulin resistance in the skeletal muscles. PMID: 23442541
    25. Neonatal mice made less PTX3 than adult mice when exposed to E. coli lipopolysaccharides. PMID: 23863905
    26. PTX3 release from a subpopulation of intrarenal mononuclear phagocytes or delayed PTX3 treatment limits postischemic renal inflammation. Ptx3 loss-of-function mutations predispose to postischemic acute kidney injury and subsequent chronic kidney disease. PMID: 23325083
    27. The local inflammatory mediator pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction. PMID: 23372656
    28. Long pentraxin-3 is an epithelial-stromal fibroblast growth factor-targeting inhibitor in prostate cancer. PMID: 23424081
    29. Endothelial PTX3 plays a pivotal role in the pathogenesis of ischemic acute kidney injury. PMID: 22895517
    30. PTX3 deficiency enhanced early infiltration of neutrophils and macrophages in the lung. PTX3 bound to MHV-1 and MHV-3 and reduced MHV-1 infectivity in vitro PMID: 22732935
    31. Assessment of pentraxin-3, an extracellular matrix protein essential for fertilization, by immunocytochemistry and Western blotting showed dramatically impaired secretion concurrent with endoplasmic reticulum stress. PMID: 22383462
    32. PTX3 located at the membrane of late apoptotic macrophages mediates their phagocytosis by phagocytes in a cell model of advanced atherosclerosis. PMID: 22173877
    33. data presented contribute to a better understanding of the pathophysiology of ventilator-induced lung injury by addressing the role of Ptx3 as a protein that exacerbates lung injury induced by high tidal volume ventilation PMID: 22425349
    34. TSG-6 reverts the inhibitory effects exerted by PTX3 on FGF2-mediated angiogenesis through competition of FGF2/PTX3 interaction. PMID: 22267482
    35. Dimer of the PTX3 is unable to rescue cumulus matrix organization, and that the tetrameric assembly of the protein is the minimal oligomeric state required for accomplishing this function. PMID: 21619930
    36. Loss-of-function mutations in the Ptx3 gene might represent a genetic risk factor for pulmonary (but not renal) manifestations of systemic lupus or other autoimmune diseases. PMID: 21637713
    37. The long pentraxin PTX3 at the crossroads between innate immunity and tissue remodelling. PMID: 21388349
    38. Cigarette smoke increases pulmonary PTX3 expression in an interleukin-1 dependent manner. PMID: 20920344
    39. molecular pathways involved in the opsonic activity of PTX3 PMID: 20829368
    40. PTX3 is a potential biomrker of acute lung injury PMID: 19921147
    41. Data point to a critical role of TSG-14 in controlling acute inflammatory response in part via the modulation of TNF-alpha expression. PMID: 12000727
    42. Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility. PMID: 12040004
    43. long pentraxin Ptx3 is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents, in particular to the opportunistic fungal pathogen Aspergillus fumigatus PMID: 12432394
    44. Addition of rPTX3, to macrophages containing Zymosan increases in phagocytosis, which parallels that of Tg-derived macrophages, demonstrating the opsonin-like activity of PTX3. PMID: 14726497
    45. Results show that PTX3 is a structural constituent of the cumulus oophorus extracellular matrix essential for female fertility. PMID: 14998931
    46. experiments suggest that PTX3 is an essential part of the ability of a host to deal with bacterial infection PMID: 16697676
    47. there is an FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region PMID: 16769728
    48. PTX3 bound both MCMV and HMCV viruses, reduced viral entry and infectivity, and protected from MCMV primary infection and reactivation through the activation of IRF3 in dendritic cells via the TLR9/MyD88-independent viral recognition sensing pathway PMID: 16840729
    49. neutrophils serve as a reservoir, ready for rapid release, of the long PTX3, a key component of humoral innate immunity with opsonic activity PMID: 17389238
    50. Pentraxin 3 is an important member of the signaling network operative in implantation and decidualization. PMID: 17538075

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: mmu:19288

    STRING: 10090.ENSMUSP00000029421

    UniGene: Mm.276776