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  4. Recombinant Mouse Peptidyl-prolyl cis-trans isomerase FKBP4 (Fkbp4)

Recombinant Mouse Peptidyl-prolyl cis-trans isomerase FKBP4 (Fkbp4)

  • 中文名称：
    小鼠Fkbp4重组蛋白
  • 货号：
    CSB-YP008700MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fkbp4重组蛋白
  • 货号：
    CSB-EP008700MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fkbp4重组蛋白
  • 货号：
    CSB-EP008700MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fkbp4重组蛋白
  • 货号：
    CSB-BP008700MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fkbp4重组蛋白
  • 货号：
    CSB-MP008700MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fkbp4; Fkpb52Peptidyl-prolyl cis-trans isomerase FKBP4; PPIase FKBP4; EC 5.2.1.8; 52 kDa FK506-binding protein; 52 kDa FKBP; FKBP-52; 59 kDa immunophilin; p59; FK506-binding protein 4; FKBP-4; FKBP59; HSP-binding immunophilin; HBI; Immunophilin FKBP52; Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4; N-terminally processed]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-458
  • 氨基酸序列
    MTAEEMKAAE NGAQSAPLPL EGVDISPKQD EGVLKVIKRE GTGTETPMIG DRVFVHYTGW LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAVATMKVG EVCHITCKPE YAYGAAGSPP KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIRTRGEG YARPNDGAMV EVALEGYHKD RLFDQRELCF EVGEGESLDL PCGLEEAIQR MEKGEHSIVY LKPSYAFGSV GKERFQIPPH AELRYEVRLK SFEKAKESWE MSSAEKLEQS NIVKERGTAY FKEGKYKQAL LQYKKIVSWL EYESSFSGEE MQKVHALRLA SHLNLAMCHL KLQAFSAAIE SCNKALELDS NNEKGLFRRG EAHLAVNDFD LARADFQKVL QLYPSNKAAK TQLAVCQQRT RRQLAREKKL YANMFERLAE EEHKVKAEVA AGDHPTDAEM KGERNNVAEN QSRVETEA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
  • 基因功能参考文献：
    1. Study demonstrates that FKBP52 by itself does not directly affect cognition and may play an indirect, modulatory role in the functional pathology of Alzheimer's disease, whereas it directly affects motor coordination, an early sign of neurodegenerative damages to the brain. PMID: 27418439
    2. identify a novel steroid-responsive FKBP52-dependent pathway suppressing the expression and activity of tryptophan-2,3-dioxygenase PMID: 25132599
    3. study identifies Fkbp4 and Fkbp5 as novel components of the Ago2 RISC loading complex PMID: 24049110
    4. FKBP52 is not involved in all branches of GR signaling, but rather acts in a gene-specific manner to regulate GR transcriptional activation. PMID: 22641006
    5. FKBP52 regulates androgen receptor function through the BF3 surface. PMID: 21730179
    6. Findings suggest that Fkbp52 deficiency diminishes the threshold against OS by reducing PRDX6 levels. PMID: 20713718
    7. Fkbp52 is an important molecular regulator in the androgen-mediated pathway of urethra morphogenesis. PMID: 20605780
    8. Data propose a model in which FKBP52 loss reduces GR control of gluconeogenesis, predisposing the liver to steatosis under HF-diet conditions attributable to a shunting of metabolism from glucose production to lipogenesis. PMID: 20427484
    9. a Hoxa10-FKBP52 signaling axis is critical to uterine receptivity and implantation PMID: 15528267
    10. FKBP52 is an AR folding factor that has critically important physiological roles in some male reproductive tissues PMID: 15831525
    11. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. PMID: 16176985
    12. indispensability of FKBP52 in uterine progesterone/progesterone receptor signaling is a function of genetic disparity and is pregnancy stage specific PMID: 17571166
    13. phosphorylation of the FK linker appears to be an important regulatory determinant of FKBP52-mediated potentiation of steroid receptor activity PMID: 17717070
    14. These results suggest that the FK1 domain, and in particular the loop overhanging the catalytic pocket, is critically involved in receptor interactions and receptor activity. PMID: 17938211
    15. Data show that the loss of FKBP52 encourages the growth of endometriotic lesions with increased inflammation, cell proliferation, and angiogenesis. PMID: 18988805
    16. FKBP52 does not contribute to all branches of GR signaling. PMID: 19073255

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  • 亚细胞定位：
    Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton.
  • 数据库链接：

    KEGG: mmu:14228

    STRING: 10090.ENSMUSP00000032508

    UniGene: Mm.12758