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  4. Recombinant Mouse Peroxiredoxin-1 (Prdx1)

Recombinant Mouse Peroxiredoxin-1 (Prdx1)

  • 货号：
    CSB-YP018653MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP018653MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP018653MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP018653MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP018653MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Prdx1; Msp23; Paga; Tdpx2; Peroxiredoxin-1; EC 1.11.1.15; Macrophage 23 kDa stress protein; Osteoblast-specific factor 3; OSF-3; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-199
  • 氨基酸序列
    SSGNAKIGY PAPNFKATAV MPDGQFKDIS LSEYKGKYVV FFFYPLDFTF VCPTEIIAFS DRADEFKKLN CQVIGASVDS HFCHLAWINT PKKQGGLGPM NIPLISDPKR TIAQDYGVLK ADEGISFRGL FIIDDKGILR QITINDLPVG RSVDEIIRLV QAFQFTDKHG EVCPAGWKPG SDTIKPDVNK SKEYFSKQK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
  • 基因功能参考文献：
    1. Data indicate the basic mechanisms connecting peroxiredoxin 1 (PRDX1) and progesterone production in the functional stage of corpus luteum (CL). PMID: 30111318
    2. These phenomena increased liver apoptosis through increasing cleaved caspase3 protein expression in Prx I/ mice after LPS injections, resulting in high lethality after LPS challenges. These findings provide a new insight for understanding the function of Prx I against endotoxininduced injury. PMID: 29901182
    3. Data suggests that Prdx1 and Prdx2 in pronuclei of zygotes are involved in antioxidant mechanisms and epigenetic programming during maternal-to-zygotic transition (during ectogenesis following in vitro fertilization). PRDX1 and PRDX2 appear to be ninth and twenty-second highest expressed proteins, respectively, among 64 proteins identified in mouse zygotes. PMID: 29503398
    4. Prdx1 knockout can aggravate the oxidative stress and lung injury by increasing the level of Reactive Oxygen Species (ROS), and also activate P38/JNK signaling pathway. PMID: 28485790
    5. validated as novel and reliable, tissue-specific reference gene in qRT-PCR studies of postnatal mammary gland development PMID: 27752147
    6. PRX1 and PRX5 were upregulated in osteoblasts in the proximal tibial metaphysis of ovariectomized mice. Interestingly, PRX1 and PRX5 showed different distribution patterns, with PRX1 mainly accumulated in cell nuclei and PRX5 in the cytoplasm. PMID: 27786251
    7. HDAC6 inhibition and the regulation of Prx1 activity may play a significant role in protecting retinal cells and in particular photoreceptors. PMID: 29048427
    8. This is the first report proclaiming that the ESAT-6 regulates Prdx-1 which is involved in the increase of mycobacterial uptake and survival. The intermediate mechanisms involve the increased Prdx-1 production in macrophages through the activation of p38 and NRF-2 dependent signaling. PMID: 29032183
    9. in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells. PMID: 27926878
    10. This study demonstrated that Prdx1 showed a distinct nuclear localization in the spinal cord also present in the nucleus of dorsal root ganglia (DRG) cells as well as in the sensory nerve root in embryonic development. PMID: 25975898
    11. Prx I and Prx II appear to have a tight association with the mechanism underlying the protection of ESC stemness in developing teratomas. PMID: 24715692
    12. Prx I is an antioxidant that is up-regulated in a reactive oxygen species/p38 MAPK-dependent manner and governs the progression of neuroinflammation by suppressing microglial activation. PMID: 23602274
    13. NO/SNO donors such as S-nitrosocysteine and S-nitrosoglutathione readily induced the S-nitrosylation of Prx1, causing structural and functional alterations PMID: 23479738
    14. PrxI is not an effective protector against ozone-induced oxidative damage but plays a positive role in the initiation of lung inflammation following exposure. PMID: 23019345
    15. Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1alpha. PMID: 23185615
    16. The clearance rate of Heinz body-containing RBCs in peroxiredoxin I(-/-) mice decreased significantly through the treatment of aniline hydrochloride (AH) compared with wild-type mice. PMID: 23101509
    17. Yiqi chutan recipe can inhibit the growth and metastasis of Lewis lung carcinoma and reduce expression of PRDX1 and PRDX6. PMID: 21434354
    18. up-regulation of Prx I gene expression by LPS is part of the cellular response to stress and may protect against oxidative stress-related injury in RAW 264.7 cells PMID: 19941984
    19. The localized inactivation of PrxI allows for the transient accumulation of H(2)O(2) around membranes, where signaling components are concentrated, while preventing the toxic accumulation of H(2)O(2) elsewhere PMID: 20178744
    20. incubation of Prx1 with thioglycollate-elicited murine macrophages or immature bone marrow-derived dendritic cells resulted in TLR4-dependent secretion of TNF-alpha and IL-6 and dendritic cell maturation PMID: 20018613
    21. Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C. PMID: 11796722
    22. induced by oxidative and nitrosative stress in pancreatic beta cells PMID: 12107731
    23. a putative tumor suppressor which interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expression PMID: 12196529
    24. results show that the sulfinic form of peroxiredoxin I, produced during the exposure of cells to H2O2, is rapidly reduced to the catalytically active thiol form PMID: 12714748
    25. mice lacking Prdx1 are viable and fertile but have a shortened lifespan owing to the development beginning at about 9 months of severe haemolytic anaemia and several malignant cancers PMID: 12891360
    26. peroxiredoxin I gene expression is activated via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway PMID: 12960165
    27. Mouse peroxiredoxin I can be successfully expressed in IEC-6 cells. PMID: 15237445
    28. mammalian sulfiredoxin reactivates hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine PMID: 15448164
    29. increase in NFkappaB activation and reactive oxygen species (ROS) levels in the cytoplasm as a result of Prdx1 knockdown PMID: 15858817
    30. Prdx1 regulates reactive oxygen species, DNA damage, and c-Myc function. PMID: 16170382
    31. Prdx1 is activated by histone deacetylase inhibitor FK228, which causes apoptosis induction in esophageal cancer cells PMID: 16278420
    32. multiple roles for Prx I in macrophage-derived foam cells that include functionality as both an antioxidant and a regulator of oxidant-sensitive signal transduction. PMID: 16880205
    33. eEF1A-2 interacts with Prdx-I to functionally provide cells with extraordinary resistance to oxidative stress-induced cell death[eEF1A-2 and Prdx-I] PMID: 16888816
    34. Expression of 40 proteins, including the antioxidative enzymes peroxiredoxin 1 and 3, glutathione peroxidase 1, and SOD-1, was increased with diabetes, suggesting an adaptive response to oxidative stress associated with this diabetic model. PMID: 17609286
    35. endogenously produced NO participates in protection of murine primary macrophages against oxidative and nitrosative stress by inducing Prx I and VI expression at mRNA and protein levels. PMID: 17921138
    36. LPS-dependent inhibition of Prx I gene activation by TPA in monocytes is regulated via a pathway that involves phosphorylation of the NF-kappaB subunit p65 at serine 276. PMID: 18070609
    37. In a spontaneous model of atherosclerosis, the antioxidant enzyme Prdx1 is shown to protect against endothelial activation and inflammation. PMID: 18689572
    38. The s found binding of the peroxidase Prdx1 to PTEN essential for protecting PTEN from oxidation-induced inactivation. PMID: 19369943
    39. Study identified the antioxidant enzyme Prdx1 as an interactor of GDE2 and uncover a developmental role for Prdx1 in regulating neuronal differentiation in the spinal cord. PMID: 19766572

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peroxiredoxin family, AhpC/Prx1 subfamily
  • 组织特异性：
    Found in various tissues; high concentration in liver.
  • 数据库链接：

    KEGG: mmu:18477

    STRING: 10090.ENSMUSP00000102078

    UniGene: Mm.30929