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  4. Recombinant Mouse Phosducin (Pdc)

Recombinant Mouse Phosducin (Pdc)

  • 货号：
    CSB-YP017663MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP017663MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP017663MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP017663MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP017663MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pdc
  • Uniprot No.：
  • 别名：
    Pdc; Rpr1; Phosducin; PHD; 33 kDa phototransducing protein; Rod photoreceptor 1; RPR-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-244
  • 氨基酸序列
    MEEAASQSLE EDFEGQATHT GPKGVINDWR KFKLESEDGD SIPPSKKEIL RQMSSPQSRD DSKERMSRKM SIQEYELIHQ DKEDESCLRK YRRQCMQDMH QKLSFGPRYG FVYELETGEQ FLETIEKEQK VTTIVVNIYE DGVRGCDALN SSLACLAVEY PMVKFCKIKA SNTGAGDRFS TDVLPTLLVY KGGELISNFI SVAEQFAEEF FAVDVESFLN EYGLLPEREI HDLEQTNMED EDIE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits the transcriptional activation activity of the cone-rod homeobox CRX. May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.
  • 基因功能参考文献：
    1. the role of phosducin at the rod-to-rod bipolar cell (RBC) synapse PMID: 24376776
    2. A major regulatory component responsible for setting the sensitivity of signal transmission between photoreceptors and ON-bipolar cells is confined to photoreceptors and that phosducin participates in the underlying molecular mechanism. PMID: 20203183
    3. Pdc-/- mice displayed exaggerated increases in blood pressure in response to post-operative stress. PMID: 19959875
    4. data suggest that phosducin action is based on the reduction of transducin affinity to the membranes of rod outer segments, achieved by keeping the transducin beta gamma subunits apart from the alpha subunit PMID: 14973130
    5. The increased retinal degeneration 1 phosducin phosphorylation coincided with increased activation of calcium/calmodulin-activated protein kinase II, which is known to utilize phosducin as a substrate. PMID: 16253986
    6. phosducin has a role in regulating signaling in the rod outer segment compartment and there are distinct functions for phosphorylation sites 54 and 71 PMID: 17569665
    7. Phosducin does not contribute to adaptation mechanisms of the outer segment by dynamically controlling heterotrimer availability, but is necessary for maintaining normal transducin expression and therefore normal flash sensitivity in rods. PMID: 17724163
    8. Dopamine and other light-dependent processes cooperatively regulate the diurnal rhythm of phosducin phosphorylation. Dopamine release in response to light and circadian clocks drives daily rhythms of protein phosphorylation in photoreceptor cells. PMID: 18547251

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  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment.
  • 蛋白家族：
    Phosducin family
  • 数据库链接：

    KEGG: mmu:20028

    STRING: 10090.ENSMUSP00000131631

    UniGene: Mm.440883