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  4. Recombinant Mouse Pinin (Pnn)

Recombinant Mouse Pinin (Pnn)

  • 中文名称：
    小鼠Pnn重组蛋白
  • 货号：
    CSB-YP018276MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pnn重组蛋白
  • 货号：
    CSB-EP018276MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pnn重组蛋白
  • 货号：
    CSB-EP018276MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pnn重组蛋白
  • 货号：
    CSB-BP018276MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pnn重组蛋白
  • 货号：
    CSB-MP018276MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pnn
  • Uniprot No.：
  • 别名：
    Pnn; Pinin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-725
  • 氨基酸序列
    AVAVRALQE QLEKAKESLK NVDENIRKLT GRDPNDVRPI QARLLALSGP GGGRGRGSLL LRRGFSDSGG GPPAKQRDLE GAVSRLGGER RTRRESRQES DPEDDDVKKP ALQSSVVATS KERTRDLIQD QNMDEKGKQR NRRIFGLLMG TLQKFKQEST VATERQKRRQ EIEQKLEVQA EEERKQVENE RRELFEERRA KQTELRLLEQ KVELAQLQEE WNEHNAKIIK YIRTKTKPHL FYIPGRMCPA TQKLIEESQR KMNALFEGRR IEFAEQINKM EARPRRQSMK EKEHQVVRNE EQKAEQEEGK VAQREEELEE TGNQHNDVEV EEAGEEEEKE AGIVHSDAEK EQEEEEQKQE MEVKTEEEAE VREGEKQQDS QPEEVMDVLE MVESVKHVIA EQEVMETNQV ESIEPSENET SKELEPEMEF DVEPDKECKS LSPGKENINS QEVEKESEEK EEKEEKEPEP QPEPVAQPQP PPQPLPQSQP HSQPHSQPQP VLQSQPLCQP ETLPLAVLQP PPQVIQEQGN LLPERKDFPL ESIKLPEVSV EPVLTVHSEN KSKNKTRSRS RGRARNKTSK SRSRSSSSSS SSSSSTSSSS GSSSSSGSSS SRSSSSSSSS TSGSSSRDSS SSTSSSSESR SRSRGRGHNR DRKHRRSMDR KRRDTSGLER SHKSSKGGSS RDRKGSKDKS SRPDRKRSIS ESSRSGKRSS RSERDRKSDR KDKRR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion.
  • 基因功能参考文献：
    1. Pnn has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium. PMID: 25489234
    2. Loss of Pnn induces apoptotic morphology in embryonic stem cells. PMID: 22454513
    3. The results suggest that astrocytes are unique among cell types of neuroblast origin in terms of expression Pinin protein. PMID: 21437620
    4. Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis PMID: 20637749
    5. Spatial and temporal expression profile of pinin during mouse development. PMID: 16427813
    6. demonstrate abnormal activities of Tcf/Lef transcription factors, and alterations in beta-catenin level in multiple Pnn hypomorphic tissues PMID: 17654715

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  • 亚细胞定位：
    Nucleus speckle. Cell junction, desmosome.
  • 蛋白家族：
    Pinin family
  • 数据库链接：

    KEGG: mmu:18949

    STRING: 10090.ENSMUSP00000021381

    UniGene: Mm.22347