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  4. Recombinant Mouse Presenilin-2 (Psen2), partial

Recombinant Mouse Presenilin-2 (Psen2), partial

  • 货号：
    CSB-YP713963MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP713963MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP713963MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP713963MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP713963MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Psen2; Ad4h; Alg3; Ps-2; Psnl2; Presenilin-2; PS-2; EC 3.4.23.-) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
  • 基因功能参考文献：
    1. These observations illustrate a novel PS2-dependent means of modulating LPS-mediated immune responses and identify a functional distinction between PS1 and PS2 in innate immunity. PMID: 26081153
    2. Although hyperactivity and hypersynchronicity were respectively detected in mice expressing the PS2-N141I or the APP Swedish mutant alone, the increase in cross-frequency coupling specifically characterized the 6-month-old PS2APP mice, just before the surge of the cognitive decline PMID: 27889678
    3. Presenilin 2 (PS2), mutations in which underlie familial Alzheimer's disease (FAD), promotes endoplasmic reticulum-mitochondria coupling only in the presence of mitofusin 2 (Mfn2). PMID: 27239030
    4. Results suggest that mutation of PS2 can lead to NF-kappaB mediate amyloidogensis, and this effect can be amplified by the absence of estrogen. PMID: 26593275
    5. The loss of PS2 could have a critical role in lung tumor development through the upregulation of iPLA2 activity by reducing gamma-secretase. PMID: 24858037
    6. One mechanism by which PS2 works to reign in proinflammatory microglial behavior and PS2 dysfunction or deficiency could result in unchecked proinflammatory activation. contributing to neurodegeneration. PMID: 23952003
    7. Interactome analyses of mature gamma-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. PMID: 23589300
    8. Distribution and expression profile of Psen2 differs from Psen1 in the cerebral cortex during development. PMID: 22796216
    9. PS2 mutation significantly accelerates the onset of cognitive impairment in associative trace eyeblink memory. PMID: 23370287
    10. Presenilin 2 has the ability to regulate nectin-1 processing. PMID: 21910732
    11. Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake PMID: 19382908
    12. Study supports the hypothesis that Pen-2 is more than a structural component of the gamma-secretase complex and may contribute to the catalytic mechanism of the enzyme. PMID: 21296884
    13. PS2 is the predominant gamma-secretase in microglia and modulates release of proinflammatory cytokines PMID: 21206757
    14. Endogenous wild-type presenilin 2 is necessary for proper protein degradation through the autophagosome-lysosome system by functioning at the lysosomal level. PMID: 21414900
    15. 4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice . PMID: 20974250
    16. partial, but highly significant, loss of mGlur2 receptors in amyloid-affected discrete brain regions of Alzheimer cases and PS2APP mice PMID: 20875805
    17. this study shows that the contribution of PS2 on gamma-secretase activity is of less importance, explaining the mild phenotype of PS2-deficient mice. PMID: 21146496
    18. inhibits protein synthesis PMID: 11817902
    19. PS2/gamma-secretase contains PEN-2 and requires it for presenilin expression PMID: 12198112
    20. Results establish a critical role of presenilin 2 in myelopoiesis; partial loss of PS2 in mice leads to age-dependent myeloproliferative disease, mediated through its gamma-secretase activity. PMID: 15122901
    21. Expression of mutant presenilin 2(M239V-PS2) caused neuronal cytotoxicity which could be inhibited by the combination of two clinically usable inhibitors of superoxide-generating enzymes, apocynin and oxypurinol PMID: 15264228
    22. The metabolic profile, however, showed clear indicators of hypometabolism with age in the PS2APP mice: both N-acetyl-aspartate and glutamate were significantly reduced in the older animals. PMID: 15649694
    23. presenilin 2 may be implicated in neuronal cell death by altering the antiapoptotic activity of the transcription factors PMID: 15858415
    24. PS2 plays an important role in cardiac excitation-contraction coupling by interacting with RyR2 PMID: 16204356
    25. the promoter of the mouse Presenilin-2 gene is bound and activated by CLOCK and BMAL1, transcription factors of the mammalian circadian clock PMID: 16887746
    26. Findings indicate that PS2 is involved in the abnormalities of the lipid profile, which could cause or result in Alzheimer's disease. PMID: 17121184
    27. C-terminal fragment of presenillin 2 is released by shedding into the extracellular compartment as a soluble form. This release is 4.07-fold increased during apoptosis. PMID: 17292944
    28. PS2 is necessary for the proteolytic activity of gamma-secretase. PMID: 17556541
    29. Thus these results demonstrate up-regulation of PS2 protein expression by sex steroids, which in turn may influence PS2 associated brain functions. PMID: 17728018
    30. Data demonstrate facilitation of ryanodine receptor gating by presenilin-2 NTF1-87. PMID: 18440065
    31. PS2 mutation causes reduction of anxiety PMID: 18803281
    32. PS2beta may inhibit gamma-secretase activity by affecting the gamma-secretase complex assembly PMID: 19376115
    33. Egr-1 over-expression and down-regulation, as well as in-vivo examination of Egr-1 and Psen2 expression during fear conditioning, showed that Egr-1 does not regulate the Psen2 promoter. PMID: 19573580

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Peptidase A22A family
  • 组织特异性：
    Ubiquitously expressed. Highly expressed in the liver.
  • 数据库链接：

    KEGG: mmu:19165

    STRING: 10090.ENSMUSP00000010753

    UniGene: Mm.330850