Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse ProSAAS (Pcsk1n)

Recombinant Mouse ProSAAS (Pcsk1n)

  • 货号：
    CSB-YP874113MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP874113MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP874113MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP874113MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP874113MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pcsk1n
  • Uniprot No.：
  • 别名：
    Pcsk1n; ProSAAS; IA-4; Proprotein convertase subtilisin/kexin type 1 inhibitor; Proprotein convertase 1 inhibitor; pro-SAAS) [Cleaved into: KEP; Big SAAS; b-SAAS); Little SAAS; l-SAAS); Big PEN-LEN; b-PEN-LEN; SAAS CT(1-49)); PEN; PEN-20; PEN-19; Little LEN; l-LEN); Big LEN; b-LEN; SAAS CT(25-40))]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    34-258
  • 氨基酸序列
    ARPVKEP RSLSAASAPL VETSTPLRLR RAVPRGEAAG AVQELARALA HLLEAERQER ARAEAQEAED QQARVLAQLL RAWGSPRASD PPLAPDDDPD APAAQLARAL LRARLDPAAL AAQLVPAPAA APRPRPPVYD DGPTGPDVED AGDETPDVDP ELLRYLLGRI LTGSSEPEAA PAPRRLRRSV DQDLGPEVPP ENVLGALLRV KRLENPSPQA PARRLLPP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.
  • 基因功能参考文献：
    1. These analyses revealed that proSAAS KO mice show blunted acute responses to cocaine- and amphetamine (AMPH) in the open field, an absence of behavioral sensitization to cocaine, an inability to maintain sensitization to AMPH, and normal responses to the rewarding properties of cocaine in conditioned place preference. PMID: 28881029
    2. proSAAS may play a role in Alzheimer's disease pathology PMID: 24102330
    3. the effects of the neuroendocrine secretory proteins proSAAS on hIAPP fibrillation in vitro and on cytotoxicity. PMID: 24042052
    4. proSAAS as a novel down-regulated target of Pax6 PMID: 23056534
    5. ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake PMID: 22164236
    6. mice lacking proSAAS have normal levels of all peptides suggesting that prohormone convertase 1 activity is not affected by the absence of proSAAS in adult mice PMID: 20367757
    7. ProSAAS and prohormone convertase 1 are broadly expressed during mouse development PMID: 15018810
    8. Although proSAAS expression overlaps with PC1 in several regions, its overall expression pattern is significantly more extensive, suggesting that proSAAS may be multifunctional during nervous system development. PMID: 15935061

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted. Golgi apparatus, trans-Golgi network.
  • 组织特异性：
    Expressed in brain (mostly hypothalamus and pituitary) and gut. Expressed in trigeminal ganglia and neuroendocrine cell lines. PEN is expressed in pancreas, spinal cord and brain (most abundant in striatum, hippocampus, pons and medulla, and cortex) (at p
  • 数据库链接：

    KEGG: mmu:30052

    STRING: 10090.ENSMUSP00000040342

    UniGene: Mm.4881