Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Progonadoliberin-1 (Gnrh1)

Recombinant Mouse Progonadoliberin-1 (Gnrh1)

  • 中文名称：
    小鼠Gnrh1重组蛋白
  • 货号：
    CSB-YP009635MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gnrh1重组蛋白
  • 货号：
    CSB-EP009635MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gnrh1重组蛋白
  • 货号：
    CSB-EP009635MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gnrh1重组蛋白
  • 货号：
    CSB-BP009635MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gnrh1重组蛋白
  • 货号：
    CSB-MP009635MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gnrh1
  • Uniprot No.：
  • 别名：
    Gnrh1; GnrhProgonadoliberin-1; Progonadoliberin I) [Cleaved into: Gonadoliberin-1; Gonadoliberin I; Gonadotropin-releasing hormone I; GnRH-I; Luliberin I; Luteinizing hormone-releasing hormone I; LH-RH I); Prolactin release-inhibiting factor 1; Prolactin release-inhibiting factor I)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-90
  • 氨基酸序列
    QHWSYGLRP GGKRNTEHLV ESFQEMGKEV DQMAEPQHFE CTVHWPRSPL RDLRGALESL IEEEARQKKM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
  • 基因功能参考文献：
    1. This work provides new findings inglucocorticoid (GC) field by bringing novel understanding on how GR integrates plasma membrane, allowing GC membrane-initiated signaling that differs in presence of GnRH to disrupt GnRH-dependent signaling and luteinizing hormone secretion. PMID: 28484221
    2. Six3 is haploinsufficient for main olfactory epithelium development, GnRH neuron migration, and fertility. PMID: 29589282
    3. The studies in this manuscript describe specific histone modifications on the enhancer and promoter of the mouse GnRH (mGnRH) gene induced by kisspeptin in GnRH neuronal cell lines. PMID: 26081144
    4. Nesfatin-1 increased Gnrh expression in hypothalamic and pituitary cells. PMID: 28339602
    5. GnRH-E1 RNA is an inducer of Gnrh1 gene expression that may play an important role in the development and maturation of GnRH neurons PMID: 27389022
    6. tet2 activity in GnRH neurons has influence over the neuroendocrine control of male reproductive function PMID: 27384303
    7. Neurons in the hypothalamus produce Kiss1 and can synchronize their activity and activate GnRH neurons thus coordinating reproduction and fertility. PMID: 27558594
    8. DHA and palmitate increase Gnrh enhancer-derived RNA levels. PMID: 26923440
    9. findings suggest that GnRH is necessary for constitutive ANXA5 expression in the pituitary gland, not only in gonadotropes but also in other pituitary gland cell types PMID: 26440525
    10. In this study, we investigate the mechanism by which VAX1 controls fertility finding that VAX1 is required for maintenance of Gnrh1 gene expression and deletion of Vax1 from GnRH neurons leads to complete infertility. PMID: 27013679
    11. RALDH and RA might not be directly involved in the reduction of GnRH expression induced by TSA, however these substances could be a novel regulator of GnRH. PMID: 26116234
    12. The profound effect of Sirt1 on the hormonal status of Sirt1(-/-) mice, mediated via defective GnRH neuronal migration, links energy metabolism directly to the hypogonadal state. PMID: 25545407
    13. neural circuits between kisspeptin and GnRH neurons in the male mouse arcuate nucleus of the hypothalamus established before birth PMID: 26172029
    14. Results demonstrate defective negative feedback in global Gpr54-null mice that cannot be attributed to a lack of prior exposure of the gonadotropin-releasing hormone neuronal network to cyclical estradiol PMID: 25301053
    15. Although levels of H2BK120ub are increased by GnRH in the coding regions of these genes, levels at the promoters do not correlate with those of H3K4me3, nor with gene expression PMID: 25591470
    16. Class IIa HDAC9 interact with Class IIb HDAC6 to modulate cell movement and survival in GnRH neurons PMID: 25873389
    17. Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in humans and mice. PMID: 25248098
    18. The aims of this study were to explore whether mRNA-levels of gonadotropin-releasing hormone (Gnrh) and its receptor (Gnrhr) were changed in plaque-bearing Alzheimer's disease transgenic mice. PMID: 25089901
    19. These observations demonstrate the necessity of perinatal GnRH signaling for driving brain sexual differentiation and indicate that kisspeptin inputs to GnRH neurons are essential for this process to occur. PMID: 25392497
    20. we did not observe any insulin-induced phospho-Akt (pAkt) or phospho-extracellular-signal-regulated kinase 1/2 in GnRH neurones PMID: 24824308
    21. Remarkably, disruption of cilia selectively on GnRH neurons leads to a significant reduction in kisspeptin-mediated GnRH neuronal activity. PMID: 24982149
    22. Sex differences in reproductive genes Gnrh1, Gad1, and Kiss1 are critically disturbed in GABAB1-deficient mice, probably altering the organization and development of neural circuits governing the reproductive axis. PMID: 24080944
    23. Data suggest GnRH neurons in forebrain express AdipoR2 (adiponectin receptor 2); adiponectin/AdipoR2 signal transduction via protein kinase C zeta/AMP-activated protein kinase down-regulates neurotransmission in subpopulation of GnRH neurons. PMID: 24564393
    24. The regulation of Homer1 splicing by GnRH contributes to gonadotropin gene control. PMID: 24591653
    25. GnRh neurons communicate with kisspeptin neurons in the embryonic arcuate nucleus. PMID: 24599473
    26. The GnRH neuron is the key site of kisspeptin-Gpr54 signaling for fertility. PMID: 24051579
    27. glucose can directly regulate GnRH transcription, while implicating the AMPK pathway as an essential mediator of nutritional signaling in a novel GnRH neuronal cell model. PMID: 23835445
    28. These data indicate regulation of GnRH release by NK3R agonists is site specific and suggest that kisspeptin is not a required mediator between NK3R activation and GnRH secretion in the median eminence. PMID: 23928373
    29. Data suggest sexual development can occur without GnRH, but GnRH or down-stream estradiol signaling is needed sometime before juvenile development for complete feminization and maximal Kiss1 (kisspeptin-1) expression in adult female thalamic nuclei. PMID: 23825121
    30. Data indicate that kisspeptin activates TRPC4 channels through PIP(2) depletion and cSrc tyrosine kinase activation in GnRH neurons. PMID: 23744639
    31. NKB could directly regulate secretion from NK3R-expressing GnRH neurons. PMID: 23393128
    32. 17beta-Estradiol exerts fundamental changes in ion channel expression in GnRH neurons. PMID: 23305677
    33. Synchronous bursts of GnRH gene transcription in the hypothalamic GnRH neuronal population in association with episodic neurohormone secretion provides insight into GnRH pulse generation. PMID: 23509283
    34. Netrin-1 directly stimulates the growth of a subpopulation of GnRH neurites PMID: 23056554
    35. Data suggest that Fgf3 (fibroblast growth factor 3) signaling is required for maintenance of Gnrh neurons in aging hypothalamus; postnatal Gnrh system is highly plastic/resilient, able to override preexisting defects and respond to external cues. PMID: 23047985
    36. These results identify beta1-integrin as a gene involved in normal development of the gonadotropin-releasing hormone system PMID: 23175850
    37. data indicate that HDAC inhibitors downregulate Gnrh1 gene expression via repressing Otx2-driven transcriptional activity. PMID: 22761896
    38. the results show that the delayed pubertal onset could be due to the inhibition of GnRH gene expression after neonatal DEX treatment PMID: 22626647
    39. Data suggest that calcineurin and NFAT4 (NFATC transcription factor 4) are required for maximal accumulation of mRNA for proto-oncogenes c-Jun and c-Fos in gonadotropes in response to GnRH. PMID: 22446101
    40. CRF suppressed GnRH protein levels PMID: 22138165
    41. Aging appears to modulate not only depolarizing afterpotential amplitude, but the effect of in vivo estradiol on sodium currents in GnRH neurons. PMID: 22209345
    42. It was concluded that elevated testosterone secretion in prenatal and neonatal mice is independent of both kisspeptin and GnRH signaling, and the necessity of kisspeptin-Kiss1r signaling for testicular function is first apparent after d 5. PMID: 22202164
    43. GnRH-1 cells differentially express the Sema7 receptors beta1-integrin and Plexin C1 as a function of their migratory stage. PMID: 21903667
    44. Data suggest that GnRH up-regulates expression/localization of Glut1 (but not Glut2, Glut4, or Glut8) and stimulates glucose utilization in gonadotrophs; effects of GnRH on Glut1 mRNA expression are partly mediated by ERK activation/phosphorylation. PMID: 22107955
    45. GABA(B) receptors are active at both pre- and postsynaptic sites to modulate the excitability of GnRH neurons; the balance of this pre- and postsynaptic activity is different between the sexes and changes in a dynamic manner across the estrous cycle. PMID: 21971155
    46. Interaction between GnRH I-RFRP-3 neuropeptides may be involved in the regulation of follicular development and atresia. PMID: 21769536
    47. Gap junctions between neuronal inputs but not gonadotropin-releasing hormone neurons control estrous cycles. PMID: 21447638
    48. CHD7 has critical roles in the development and maintenance of GnRH neurons for regulating puberty and reproduction. PMID: 21596839
    49. SOX-C transcription factors function as important transcriptional regulators of cell type-specific gonadotropin releasing hormone gene expression PMID: 21527504
    50. current results show that the action of GnRH in the regulation of gonadotropin subunit expression is enhanced by the presence of PAC1Rs PMID: 21658369

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    GnRH family
  • 数据库链接：

    KEGG: mmu:14714

    STRING: 10090.ENSMUSP00000106724

    UniGene: Mm.358309