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  4. Recombinant Mouse Protachykinin-1 (Tac1)

Recombinant Mouse Protachykinin-1 (Tac1)

  • 中文名称：
    小鼠Tac1重组蛋白
  • 货号：
    CSB-YP023062MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tac1重组蛋白
  • 货号：
    CSB-EP023062MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tac1重组蛋白
  • 货号：
    CSB-EP023062MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tac1重组蛋白
  • 货号：
    CSB-BP023062MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tac1重组蛋白
  • 货号：
    CSB-MP023062MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tac1
  • Uniprot No.：
  • 别名：
    Tac1; Nka; Nkna; Tac2; Protachykinin-1; PPT) [Cleaved into: Substance P; Neurokinin A; NKA; Neuromedin L; Substance K); Neuropeptide K; NPK); Neuropeptide gamma; C-terminal-flanking peptide]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    58-68
  • 氨基酸序列
    RPK PQQFFGLM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
  • 基因功能参考文献：
    1. these results show that substance P regulates the production of LTB4 via PKCalpha/MAPK pathway, which further promotes AP-associated ALI through neutrophil reverse transendothelial cell migration PMID: 29482159
    2. This study demonstrated that BoNT/A antinociceptive activity is dependent on integrity of SP/NKA and NK1R. PMID: 28673722
    3. elevated plasma SP level, up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis. PMID: 28460633
    4. SP treatment inhibited inflammatory responses by modulating cytokine production as well as the balance of Tregs/Th 17 cells and the M1/M2 transition in lymphoid organs, leading to accelerated tissue repair. PMID: 27750083
    5. This study demonstrated that there is an additional population of neurons that transiently express Preprotachykinin A in the mouse superficial spinal dorsal horn including cells that respond to noxious and pruritic stimuli. PMID: 27902570
    6. Evidence for a role of Tac1 in the control of reproductive function in the male mouse, suggesting a predominant central action that may involve a change in the balance of neural factors that control GnRH expression. PMID: 28444173
    7. This study demonstrated that Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex. PMID: 28073937
    8. RNA-binding protein Msi1 competes with miR130a and -206 for interaction with TAC1 mRNA, to stabilize and increase its translation PMID: 26373800
    9. Results reveal that EM-2, Leu-Enk and Dyn A were down-regulated in Tac1-/- spinal cord tissues. PMID: 26072188
    10. Results provide evidence linking enhanced waking activity and the pro-inflammatory molecule substance P to changes in slow-wave activity associated with sleep-active cortical cells that co-express nNOS and the NK-1R PMID: 25301750
    11. Substance P partly accounts for the increased density of microglia in the substantia nigra through chemotaxic recruitment via a novel NK1R-NOX2 axis-mediated pathway. PMID: 26223840
    12. The spatial structures of human, mouse, and rat hemokinin-1 protein isoforms have been presented. PMID: 26349209
    13. We conclude that a dedicated subset of VMHVL neurons marked by ERalpha, NKX2-1, and Tac1 regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses. PMID: 25543145
    14. Data demonstrate a role TAC1 in the control energy balance by regulating the levels of adiposity in response to ghrelin administration and to changes in the status of the gonadal function. PMID: 25751638
    15. Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification. PMID: 25063231
    16. In vivo ozone(O3)-induced elevations in both nerve growth factor (NGF) and substance P (SP) are mediated by the inflammatory cytokine interleukin-1beta. Further, inhibition of NGF reduced O3 induced increases of SP in both the lung BALF and lung tissue. PMID: 25734767
    17. potent regulation of gonadotropin release by the SP/NK1R and NKA/NK2R systems in the presence of kisspeptin-Kiss1r signaling PMID: 25422875
    18. This study demonistration that Acid could mediate a prolonged antinociceptive signaling via the release of substance P from muscle afferent neurons in a non-ASIC3, non-TRPV1 manner. PMID: 24886508
    19. Basal postoperative microcirculation on the plantar skin of PACAP(-/-) mice did not differ from the wildtypes, but was significantly lower in Tac1(-/-) and Tacr1(-/-) ones. PMID: 23499760
    20. SP-, CGRP-, and VGLUT2-mediated transmission together were found to play a role in the development of mechanical hyperalgesia after persistent inflammation. PMID: 24275230
    21. Data indicate that transient receptor potential ion channels and neuropeptides substance P and calcitonin gene-related peptide have important roles in formaldehyde promoted-asthma. PMID: 23671638
    22. Hemokinin-1, but not substance P increases inflammation and hyperalgesia in the late phase of adjuvant-induced arthritis. PMID: 23626716
    23. Reactive oxygen species plays a role in regulation of psychoemotional stress induced Substance P-mast cell pathway. PMID: 23637859
    24. These findings suggest that tachykinins and NK1 receptors play a key role in joint inflammation, rather than in nociceptive sensitization, in collagen antibody-induced arthritis A. PMID: 22687356
    25. focal loss of SP and early inflammatory changes in the substantia nigra precede remote neuronal injury after striatal ischemic damage PMID: 23232501
    26. results showed that under transcriptional regulation of BMAL1:CLOCK heterodimers, substance P's coding gene Tac1 expression oscillates in dorsal root ganglion PMID: 22634872
    27. Morphine enahnces the hypoxic ventilatory response in newborn Tac1-deficient mice. PMID: 23065762
    28. Substance P induces the activation of NK-1 receptor regulating melanin biosynthesis. PMID: 23041339
    29. 8 days of SP supplementation during differentiation to 3T3-L1 preadipocytes decreased lipid droplet accumulation, increased lipolysis and reduced fatty acid uptake. PMID: 23257919
    30. Semapimod increases neuronal SP levels in tumor-bearing mice. PMID: 22982142
    31. elevated SP levels during DOCA-salt hypertension play a significant role contributing to renal damage PMID: 23024265
    32. the up-regulation of substance P and down-regulation of mu-opioid receptor seen in the dorsal root ganglia may be, at least in part, responsible for the abdominal pain-like state associated with peritoneal carcinomatosis PMID: 22913923
    33. Release of substance P after experimental retinal laser burn contributes to loss of immune regulation in both the burned and nonburned eye. PMID: 22745377
    34. proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons PMID: 22080974
    35. SP, neurokinin type 1 (NK-1) receptor, alpha-adrenergic receptor (alpha-AR), and beta-AR were abundantly expressed in primary costal chondrocytes. PMID: 22042746
    36. Human progenitor cells (PC) express NK1, and substance p-induced migration provides enrichment for proangiogenic PC PMID: 22392530
    37. H(2)S regulates TRPV1-mediated neurogenic inflammation in polymicrobial sepsis through enhancement of SP production and activation of the ERK-NF-kappaB pathway PMID: 21931742
    38. Intrathecal injection of substance P amino-terminal fragment 1-7 into mice results in attenuation of paw-licking/biting behavior induced by capsaicin intraplantar injection. PMID: 21601581
    39. An antinociceptive role for substance P in acid-induced chronic muscle pain. PMID: 22084095
    40. Substance P may be important in mediating adverse myocardial remodelling secondary to volume overload by activating cardiac mast cells, leading to increased TNF-alpha and MMP activation with subsequent degradation of the extracellular matrix. PMID: 21908647
    41. Results demonstrate the relative contribution of substance P in regulating the clinical severity of herpes keratitis lesions in a mouse model. PMID: 21969295
    42. Activation and sensitization of TRPA1 and release of substance P induce and maintain colitis in mice. PMID: 21763243
    43. Substance P and NK-1R alters adipose tissue responses to high-fat diet and insulin action. PMID: 21467195
    44. PPTA gene deletion reduced TLR4, myeloid differentiation factor 88, interleukin 1 receptor-associated kinase 4, tumor necrosis factor receptor-associated factor 6, and NF-kappaB in cerulein-treated pancreatic acinar cells. PMID: 21289528
    45. Nasal allergen provocation rapidly induces bronchial hyperresponsiveness via pulmonary up-regulation of SP and activation of NK1 receptors. PMID: 20539012
    46. Results suggest the presence of an autocrine loop that controls the expression of the TAC1 promoter in sensory neurones. PMID: 21294877
    47. Results confirm an important role for TAC1 and NK1(R) in the control of viral infection but reinforce the complex nature of the peptide-receptor interactions. PMID: 21106239
    48. Data show that delta opioid receptor (DOPR)-mediated analgesia is not altered in preprotachykinin A knockout mice, and that substance P is not essential for membrane insertion and for the functional emergence of DOPR. PMID: 21044181
    49. Sensory neuropeptide SP activation of dendritic cells during the effector phase of T helper (Th) type 1 cell-driven inflammation triggers a massive and rapid Langerhans cell mobilization in the epidermis that enhances inflammation. PMID: 21172866
    50. we show for the first time that Substance P-NK1R signaling markedly elevates COX-2 activity via ERK1/2 and NF-kappaB, leading to remote Acute lung injury after burn PMID: 20926798

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Tachykinin family
  • 数据库链接：

    KEGG: mmu:21333

    STRING: 10090.ENSMUSP00000088175

    UniGene: Mm.1440