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  4. Recombinant Mouse Proteasome subunit beta type-11 (Psmb11)

Recombinant Mouse Proteasome subunit beta type-11 (Psmb11)

  • 货号：
    CSB-YP806814MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP806814MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP806814MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP806814MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP806814MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Psmb11
  • Uniprot No.：
  • 别名：
    Psmb11; Proteasome subunit beta type-11; EC 3.4.25.1; Proteasome subunit beta-5t
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    50-302
  • 氨基酸序列
    T TTLAFRFRHG VIAAADTRSS CGSYVACPAS RKVIPVHQRL LGTTSGTSAD CATWYRVLRR ELRLRELREG QLPSVAGTAK LLAAMMSCYR GLDLCVATAL CGWDHSGPAL FYVYSDGTCL QGDIFSVGSG SPYAYGVLDR GYHYDMTIQE AYTLARCAVA HATHRDAYSG GSVDLFHVRE SGWEYVSRSD ACVLYRELQK ARSLEQELEA KACGIYPEPA TPQGARECKE LFVEQEEVTP EDCAIIMKTE TM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T-cells.
  • 基因功能参考文献：
    1. Study report the identification of a highly conserved Foxn1-binding sequence that is located proximal to the beta5t-coding sequence in the mouse genome. This cis-regulatory element is indeed essential for the optimal expression of beta5t in cortical thymic epithelial cells and the optimal production of CD8+ T cells. PMID: 28176764
    2. beta5t-containing thymoproteasomes contribute to the positive selection of CD8+ T cells by preferentially producing low-affinity TCR ligand peptides. PMID: 26099460
    3. The current data showed that impaired proteasomal function causes photoreceptor degeneration. PMID: 24994871
    4. Results indicate that the majority of thymic medullary epithelial cells (mTECs) are derived from beta5t-expressing progenitor cells. PMID: 23720310
    5. Thymoproteasome subunit-beta5T generates peptide-MHC complexes specialized for positive selection. PMID: 23569244
    6. results indicate that beta5t expression in thymic cortical epithelial cells is dependent on Foxn1 but independent of thymocyte crosstalk or thymic medulla formation PMID: 21469133
    7. results suggest a key role for proteasome subunit beta5t in generating the MHC class I-restricted CD8(+) T cell repertoire during thymic selection PMID: 17540904

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1B family
  • 组织特异性：
    Expressed exclusively in cortical thymic epithelial cells.
  • 数据库链接：

    KEGG: mmu:73902

    STRING: 10090.ENSMUSP00000132140

    UniGene: Mm.32009