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  4. Recombinant Mouse Proteasome subunit beta type-9 (Psmb9)

Recombinant Mouse Proteasome subunit beta type-9 (Psmb9)

  • 中文名称：
    小鼠Psmb9重组蛋白
  • 货号：
    CSB-YP018887MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Psmb9重组蛋白
  • 货号：
    CSB-EP018887MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Psmb9重组蛋白
  • 货号：
    CSB-EP018887MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Psmb9重组蛋白
  • 货号：
    CSB-BP018887MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Psmb9重组蛋白
  • 货号：
    CSB-MP018887MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Psmb9
  • Uniprot No.：
  • 别名：
    Psmb9; Lmp2; Ring12; Proteasome subunit beta type-9; EC 3.4.25.1; LMP-2d; Low molecular mass protein 2; Macropain chain 7; Multicatalytic endopeptidase complex chain 7; Proteasome chain 7; Proteasome subunit beta-1i; Really interesting new gene 12 protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    21-219
  • 氨基酸序列
    TTIMAVEFDG GVVVGSDSRV SAGTAVVNRV FDKLSPLHQR IFCALSGSAA DAQAIADMAA YQLELHGLEL EEPPLVLAAA NVVKNISYKY REDLLAHLIV AGWDQREGGQ VYGTMGGMLI RQPFTIGGSG SSYIYGYVDA AYKPGMTPEE CRRFTTNAIT LAMNRDGSSG GVIYLVTITA AGVDHRVILG DELPKFYDE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Contributes to NFKBIA degradation and subsequently NFKB1 generation.
  • 基因功能参考文献：
    1. down-regulation of IL-33 protein levels by IFN-gamma in pulmonary fibroblasts and in the lungs in vivo occurs through STAT1 and non-canonical use of the LMP2 proteasome PMID: 24619410
    2. Data show that knockdown of i-proteasome catalytic subunit PSMB9 by short hairpin RNA (shRNA) decreased the expression of both PSMB9 and PSMB8 without affecting other catalytic subunits of the proteasome. PMID: 24164898
    3. LMP2 has a role as a tumor-suppressor and may have a role in uterine leiomyosarcoma therapy PMID: 22355695
    4. In this study, we have identified how LMP2 can exert its function in Ag processing PMID: 22772448
    5. Mixed proteasomes present in LMP2-deficient mice compromise virtually every parameter of the immune response against influenza A virus, potentially through dysregulation of signaling pathways, such as the nuclear factor (NF)-kappaB pathway. PMID: 20228196
    6. Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice. PMID: 11782352
    7. The presence of immuno subunits in nonimmune tissues such as lens suggests that the immunoproteasome may also have nonimmune functions, such as that in lens differentiation. PMID: 12220526
    8. Comparison of LMP2 KO mice and non-transgenic mice of the same background show that LMP2 KO mice exhibit a higher degree of motor function, but possess a similar level of cognitive function and ambulation. PMID: 15036617
    9. Immunoproteasome LMP2 can at least in part determine subdominance and shape the epitope hierarchy of cytotoxic T cell responses in vivo. PMID: 15356141
    10. Immunoproteasome LMP2 may affect CD8+ T cell responses to only a limited number of viral epitopes; its main biological function may lie elsewhere. PMID: 16002717
    11. These results demonstrate the ability of the IFN-induced proteasome catalytic subunits to shape the HBV-specific CD8 T-cell response and thus potentially influence the progression of infection to acute or chronic disease. PMID: 17079320
    12. two inducible subunits of the proteasome, lmp2 and lmp7, are transcriptionally up-regulated by heat shock; heat-shocked cells show enhanced presentation of immunoproteasome-dependent MHC I antigenic epitopes, but not immunoproteasome-independent epitopes PMID: 17142736
    13. SOD1/LMP2-/- mice show no change in motor function decline, or survival compared to G93A SOD1 mice, suggesting that the loss of immuno-proteasome function in vivo does not significantly alter mutant SOD1-induced disease. PMID: 17482163
    14. LMP-2 is required for normal proteasomal function and ischemic preconditioning induction in the heart. Its action may be related to PTEN protein degradation. PMID: 18728217

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1B family
  • 组织特异性：
    Detected in liver (at protein level). Expressed at high levels in the thymus, spleen, lung, heart and liver. Expressed at moderate levels in the kidney.
  • 数据库链接：

    KEGG: mmu:16912

    STRING: 10090.ENSMUSP00000133499

    UniGene: Mm.390983