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  4. Recombinant Mouse Protein CBFA2T3 (Cbfa2t3)

Recombinant Mouse Protein CBFA2T3 (Cbfa2t3)

  • 货号：
    CSB-YP004576MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004576MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004576MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004576MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004576MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cbfa2t3
  • Uniprot No.：
  • 别名：
    Cbfa2t3; Cbfa2t3h; Mtgr2; Protein CBFA2T3; Eight twenty one protein 2; MTG8-related protein 2; Protein ETO-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-620
  • 氨基酸序列
    MSQASTTTLE SGALLSGPRG LQYGSPAHRK EKAAAMPDSP AEVKTQPRST PPSMPPPPPT SSQGATRPPS FTPHTHGEDG PATSLPHGRF HGCLKWSMVC LLMNGSSHSP TAIHGAPSTP NGFSNGPATS STASLSTQHL PPACGARQLS KLKRFLTTLQ QFGSDISPEI GERVRTLVLG LVNSTLTIEE FHAKLQEATN FPLRPFVIPF LKANLPLLQR ELLHCARLAK QTPAQYLAQH EQLLLDASAT SPVDSSELLL EVNENGKRRT PDRTKENGSD RDPLHPDHLS KRSCTLSPAQ RCSPSNGLPH PTPPPPPHYR LEDMAMAHHF RDSYRHPDPR ELRERHRPLA IPGSRQEEVI DHRLTEREWA EEWKHLNSLL NCIMDMVEKT RRSLTVLRRC QEADREELNH WIRCYSDSEE GKKGPTPISA RSLNSCSGPE GSQLDVHRDF TPRTLSGYMP EEIWRKAEEA VNEVKRQAMS ELQKAVSDAE RKAHELITTE RAKMERALAE AKRQASEDAL TVINQQEDSS ESCWNCGRKA SETCSGCNAA RYCGSFCQHK DWEKHHHVCG QSLQGPAAAV ADPLPGQPDA TASPSEAGSA GPSRPCSPGP PGPLDAAVPR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.
  • 基因功能参考文献：
    1. gene deficient mice have decreased levels of systemic monocytes and infarct-associated macrophages and display compromised tissue healing and post-MI heart failure PMID: 25957903
    2. MTG16 loss promotes radioresistance and impacts intestinal stem cell function, possibly due to shifting cellular response away from DNA damage-induced apoptosis and towards DNA repair after injury. PMID: 25573176
    3. Mtg16 promotes plasmacytoid dendritic cell differentiation and restricts classical dendritic cell development in part by repressing Id2. PMID: 24980046
    4. MTG16 is critical for colonocyte survival and regeneration in response to intestinal injury and provide evidence that this transcriptional corepressor regulates inflammatory recruitment in response to injury. PMID: 22833394
    5. Mtg16 integrates the activities of signaling pathways and nuclear factors in the establishment of T-cell fate specification. PMID: 21536648
    6. Data suggest that MTG16 interfaces with critical components of the Notch transcription complex to affect Notch-dependent lineage allocation in hematopoiesis. PMID: 20123979
    7. association with T-cell acute lymphocytic leukemia 1, ETO-2 represses gene expression in the early stages of erythroid differentiation PMID: 16287841
    8. The dynamics of ETO2 recruitment within nuclear complexes couple cell proliferation to cell differentiation and determine the onset of terminal erythroid maturation. PMID: 16407974
    9. MTG8/ETO and Mtg16 (also known as ETO2) associated with TCF4 PMID: 18039847
    10. These data suggest that ETO2 directly represses inappropriate early expression of a subset of terminally expressed megakaryocyte genes by binding to GATA1 and SCL. PMID: 18625887
    11. the transcriptional corepressor Mtg16 (myeloid translocation gene on chromosome 16), which is targeted by t(16;21) in acute myeloid leukemia, is required for hematopoietic progenitor cell fate decisions and for early progenitor cell proliferation. PMID: 18710942

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  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Golgi apparatus membrane.
  • 蛋白家族：
    CBFA2T family
  • 组织特异性：
    Widely expressed with higher expression in heart, brain, lung and spleen. Expressed in hematopoietic cells (at protein level).
  • 数据库链接：

    KEGG: mmu:12398

    STRING: 10090.ENSMUSP00000118997

    UniGene: Mm.194339