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  4. Recombinant Mouse Protein NDRG2 (Ndrg2)

Recombinant Mouse Protein NDRG2 (Ndrg2)

  • 中文名称：
    小鼠Ndrg2重组蛋白
  • 货号：
    CSB-YP879456MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ndrg2重组蛋白
  • 货号：
    CSB-EP879456MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ndrg2重组蛋白
  • 货号：
    CSB-EP879456MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ndrg2重组蛋白
  • 货号：
    CSB-BP879456MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ndrg2重组蛋白
  • 货号：
    CSB-MP879456MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ndrg2
  • Uniprot No.：
  • 别名：
    Ndrg2; Kiaa1248; Ndr2; Protein NDRG2; N-myc downstream-regulated gene 2 protein; Protein Ndr2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-371
  • 氨基酸序列
    AELQEVQIT EEKPLLPGQT PETAKEAELA ARILLDQGQT HSVETPYGSV TFTVYGTPKP KRPAIFTYHD VGLNYKSCFQ PLFRFGDMQE IIQNFVRVHV DAPGMEEGAP VFPLGYQYPS LDQLADMIPC ILQYLNFSTI IGVGVGAGAY ILSRYALNHP DTVEGLVLIN IDPNAKGWMD WAAHKLTGLT SSIPDMILGH LFSQEELSGN SELIQKYRGI IQHAPNLENI ELYWNSYNNR RDLNFERGGE TTLKCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP GKLTEAFKYF LQGMGYMASS CMTRLSRSRT ASLTSAASID GSRSRSRTLS QSSESGTLPS GPPGHTMEVS C
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.
  • 基因功能参考文献：
    1. Immunohistological analysis showed that the expression of NDRG2 increases dominantly in astrocytes following permanent middle cerebral artery occlusion (MCAO). Genetic deletion of Ndrg2 exhibited enhanced levels of infarct volume and accumulation of immune cells into the ipsilateral brain hemisphere following ischemia. Expression of matrix metalloproteinases (MMPs) after MCAO markedly increased in Ndrg2(-/-) mice. PMID: 29476556
    2. Increased level of NDRG2 in cortex or hippocampus may be a potential risk for Alzheimer's disease. NDRG2 increased Abeta1-42 might be related to the changes of BEAC1 and GGA3. It might also affect CDK5 and tau overphosphorylation. NDRG2 interacting with STAT3 and modulating Fas/Fasl signaling pathway plays important roles in cell death. PMID: 28670853
    3. These findings provide insight into the role of NDRG2 in ischemic-hypoxic injury and provide potential targets for future clinical therapies for stroke. PMID: 27154863
    4. NDRG2 is a novel ERS-responsive protein and acts as PERK co-factor to facilitate PERK branch, thereby contributing to ERS-induced apoptosis. PMID: 28948615
    5. Our results show how NDRG2 expression serves as a critical determinant of the invasive and metastatic capacity of oral squamous cell carcinoma (OSCC) PMID: 28209617
    6. Using double knockout of NDR1 and 2 shows that NDRs acted downstream of MST1 to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naive T cells within popliteal lymph nodes. PMID: 26443704
    7. The expression level of NDRG2 has a causal influence on mood-related phenotypes. PMID: 26208882
    8. Ndr1/2-double null embryos show defects in somitogenesis and cardiac looping, which reveals their essential functions and shows that the NDR kinases are critically required during the early phase of organogenesis PMID: 26305214
    9. NDRG2 is associated with decidualization during early pregnancy. PMID: 26013399
    10. NDRG2 accumulated in skeletal muscle and myoblasts in the absence of TRIM32. NDRG2 overexpression in myoblasts led to reduced cell proliferation and delayed cell cycle withdrawal during differentiation. PMID: 25701873
    11. Electroacupuncture administration can alleviate reference memory deficits and suppress N-myc downstream-regulated gene 2 upregulation in an AD transgenic mouse model PMID: 24390566
    12. Rassf5 and Ndr1 or Ndr2 kinases regulate neuronal polarity through Par3 phosphorylation. PMID: 24928906
    13. Ndrg2 plays a key role in reactive astrogliosis after cortical stab injury through a mechanism involving the positive regulation of IL-6/STAT3 signaling PMID: 24697507
    14. Ndr2 controls beta1-integrin phosphorylation and trafficking crucial for neurite growth. PMID: 24719112
    15. Data indicate that N-myc downstream-regulated gene 2 (NDRG2) is a novel direct target gene of farnesoid X receptor (FXR) in mouse liver and human hepatoma cell lines PMID: 23056173
    16. Loss of Ndrg2 resulted in vertebral homeotic transformations in thoracic/lumbar and lumbar/sacral transitional regions in a dose-dependent manner. PMID: 22819676
    17. Study reveals that ndrg2 is a novel gene that participates in Leydig cell apoptosis, with essential functions in testicular cells, and suggests its possible role in apoptotic Leydig cells and male fertility. PMID: 22138128
    18. abundant expression of Ndrg2 mRNA in neural proliferating cell populations indicates an important role of Ndrg2 in neurogenesis of both embryonic and postnatal mouse brain. PMID: 22143493
    19. results suggest that Ndrg2 may regulate astroglial activation through the suppression of cell proliferation and stabilization of cell morphology PMID: 21672576
    20. data identify Ndrg2 as a novel insulin-dependent phosphoprotein and suggest that PKC theta may inhibit insulin action in part by reducing its phosphorylation by Akt. PMID: 14985363
    21. These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain. PMID: 17998568
    22. Ndrg2 was expressed in different regions of the brain, including the cerebral cortex, olfactory bulb, midbrain, hippocampus, and thalamus, with high levels in the midbrain and thalamus. PMID: 18520995
    23. NDRG2 gene expression in B16F10 melanoma cells restrains melanogenesis via inhibition of Mitf expression. PMID: 19067970
    24. NDRG2 expression is highly responsive to different stress conditions in skeletal muscle and suggest that the level of NDRG2 expression may be critical to myoblast growth and differentiation. PMID: 19204049
    25. NDRG2 expression significantly suppresses tumor invasion by inhibiting MMP activities, which are regulated through the NF-kappaB signaling PMID: 19336468

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone.
  • 蛋白家族：
    NDRG family
  • 组织特异性：
    Expressed at highest levels in brain, heart and liver, and at lower levels in kidney, colon, skeletal muscle, adrenal gland, ovary and uterus (at protein level).
  • 数据库链接：

    KEGG: mmu:29811

    STRING: 10090.ENSMUSP00000004673

    UniGene: Mm.26722