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  4. Recombinant Mouse Protein RCC2 (Rcc2)

Recombinant Mouse Protein RCC2 (Rcc2)

  • 货号：
    CSB-YP806859MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP806859MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP806859MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP806859MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP806859MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rcc2
  • Uniprot No.：
  • 别名：
    Rcc2; Kiaa1470; Protein RCC2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-520
  • 氨基酸序列
    MPRKKGAAWE EPSSGNGTAR AGPRRRGGPA GRKRERPERC SSSSGGGSSG DEDGPELDGA PGGGKRTARP ATAGKAAGAA AIITEPEHTK ERVKLEGSKC KGQLLIFGAT NWDLIGRKEV PKQQAAYRNL GQNLWGPHRY GCLSGVRVRT VVSGSCAAHS LLITTEGKLW SWGRNEKGQL GHGDTKRVEA PRLIEALSHE AIVLAACGRN HTLALTDTGS VFAFGENKMG QLGLGNQTDA VPSPAQIMYN GQPITKMACG AEFSMLMDCK GNLYSFGCPE YGQLGHNSDG KFIARAQRIE YDCELVPRRV AIFIEKTKDG QILPVPNVVV RDVACGANHT LVLDSQKRVF SWGFGGYGRL GHAEQKDEMV PRLVKLFDFP GRGATQIYAG YTCSFAVSEV GGLFFWGATN TSRESTMYPK AVQDLCGWRI RSLACGKSSI IVAADESTIS WGPSPTFGEL GYGDHKPKSS TAAQEVKTLD GIFSEQVAMG YSHSLVIARD ESEAEKEKLQ RLPEYTPRTL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Functions as guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors. Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions. Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro).
  • 基因功能参考文献：
    1. EGFR suppression of mitotic regulators including Rcc2 and Stathmin 1 are a mechanism for catagen induction in mouse skin PMID: 26661905
  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome. Midbody. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 数据库链接：

    KEGG: mmu:108911

    STRING: 10090.ENSMUSP00000038144

    UniGene: Mm.253