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  4. Recombinant Mouse Protein SGT1 homolog (Ecd)

Recombinant Mouse Protein SGT1 homolog (Ecd)

  • 中文名称：
    小鼠Ecd重组蛋白
  • 货号：
    CSB-YP875134MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ecd重组蛋白
  • 货号：
    CSB-EP875134MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ecd重组蛋白
  • 货号：
    CSB-EP875134MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ecd重组蛋白
  • 货号：
    CSB-BP875134MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ecd重组蛋白
  • 货号：
    CSB-MP875134MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ecd
  • Uniprot No.：
  • 别名：
    EcdProtein ecdysoneless homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-641
  • 氨基酸序列
    MEGSGKLAMV EDAVEYHLFL IPDKARGTEE HREILQKYIE RIMTQFAPIL VPYIWQNQPF NLKYKPAKGG VPAHMYGMTK FGDNIEDEWF IVYVIKQITK EFPELVARVE DNDGEFLLIE AADFLPKWLD PDNSANRVFF HHGELCIIPV PRKSERIPWL PMTPPTIQQA LSIISAHPEA VLASESIQAA VDRRVSGYPE RVEASLHRAH CFLPAGIVAV LKQQPRLLSA AVQAFYLRDP IDLRACRVFK TFLPETRIMA SVTFTKCLYA QLVQQKFVPD RRSGYGLPPP SHPQYRAYEL GMKLAHGFEI LCSKCSPHFS DSRKSLVTAS PLWASFLESL KRNDYFKGLM DGSAQYQERL EMAKNYFQLS IHRPESSLAM SPGEEILTVL QTQPFDVAEL KTEEADLPPE DDDQWLDLSP DQLDQLLQDA AGRKESQPGP QKEELQNYDV AQVSDSMKAF ISKVSSHKGA ELPRDPSEAP ITFDADSFLN YFDKILGAKP QESDSEDDPG EEDVEGVDSD DDVGFEAQES ESLKGALGSL KSYMARMDQE LAHTSMGRSF TTRERLNKDP PSHTANDNSD EEDSGAGDCA VEAVDVDLNL ISNILESYSS QAGLAGPASN LLHSMGVRLP DNADHNPQVS Q
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
  • 基因功能参考文献：
    1. The data demonstrate that ECD promotes survival upon endoplasmic reticulum stress by increasing GRP78 protein levels to enhance the adaptive folding protein in the endoplasmic reticulum to attenuate PERK signaling. PMID: 28652267
    2. Results demonstrate that mammalian Ecd plays a role in cell cycle progression via the Rb-E2F pathway. PMID: 19640839
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    ECD family
  • 数据库链接：

    KEGG: mmu:70601

    STRING: 10090.ENSMUSP00000022344

    UniGene: Mm.35105