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  4. Recombinant Mouse Protein fuzzy homolog (Fuz)

Recombinant Mouse Protein fuzzy homolog (Fuz)

  • 货号：
    CSB-YP668900MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP668900MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP668900MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP668900MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP668900MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fuz
  • Uniprot No.：
  • 别名：
    FuzProtein fuzzy homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-415
  • 氨基酸序列
    MGDEGPGSPV HLLCLAASSG VPLFCRSSSG GAPSRQQLPF SVIGSLNGVH MFGQNLDVQL NSARTEDTTV VWKNFHDSIT LIVLSSEEGT SELRLERMLH MVFGAMVLIV GLEELTNIRN VERLKKELRA SYCLIDSFLG NSELIGDLTQ CVDCVIPPEG SAMQETLSGF AEATGTAFVS LLVSGRVVAA TEGWWRLGMP EAVLLPWLVG SLPPQAARDY PVYLPHGSPT VPHRLLTLTL LRGLELCLLC GPRPPLGQLD PQLMERWWQP LLEPLRACLP LGPRALPEGF PLHSDILGLL LLHLELRRCL FTMEPSKDKE PSPEQRRRLL RNFYTLVATT HFPPEPGPAE KQEDTVYPAQ MPRACYLVLG PGMGWQLVAV QLGLRLLLLL LSPHTPTHGL RSLATRTLQA LTPLL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia.
  • 基因功能参考文献：
    1. This paper reports a novel skull phenotype in a ciliopathic mutant mouse in which only a single calvarial bone plate encases the forebrain in mice lacking Fuz, an essential regulator of ciliogenesis. PMID: 27395007
    2. Fuzzy appears to control subcellular localization of the core PCP protein Dishevelled, recruiting it to Rab8-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP signaling PMID: 23303251
    3. Using the ciliopathic Fuz mutant mouse, we find that high arched palate does not, as commonly suggested, arise from midface hypoplasia; rather, increased neural crest expands the maxillary primordia. PMID: 23806618
    4. Data report the dynamic expression of another planar cell polarity gene, Fuzzy, during neural tube formation in mice. PMID: 21840926
    5. The data demonstrate a new model for coordination of Hh and Wnt signaling and reveal a Fuz-dependent negative feedback loop controlling Wnt/beta-catenin signaling. PMID: 21935430
    6. Data show that the functions of both Inturned and Fuzzy in neural tube patterning are dependent on the presence of cilia. PMID: 21761479
    7. Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia. PMID: 20962855
    8. Fuz plays an important role in cilia formation, Hh signal transduction, and embryonic development in mammals. PMID: 19877275

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    Fuzzy family
  • 组织特异性：
    Expressed in dermal and epidermal cells.
  • 数据库链接：

    KEGG: mmu:70300

    STRING: 10090.ENSMUSP00000071194

    UniGene: Mm.276298