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  4. Recombinant Mouse Protein inscuteable homolog (Insc)

Recombinant Mouse Protein inscuteable homolog (Insc)

  • 货号：
    CSB-YP661673MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP661673MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP661673MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP661673MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP661673MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Insc
  • Uniprot No.：
  • 别名：
    Insc; Protein inscuteable homolog; Minsc
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-579
  • 氨基酸序列
    MRRPPGDGDS TGEGPGNWGL WGAQESRRLC CVGPDRCGQA LLQIGINMMA LPGGRHLDSV PLQEQRLHFM QVDSVQRWME DLKLMTECEC MCVLQAKPIS LEEDTQGDLI LAGGPGPGDP LQLLLKRGWV ISTELRRIGQ KLAQDRWARV HSMSVRLTCH ARSMVSEYST ISRTASQEMG QAEKLLMEKC SELSAVTERC LQVENEHVLK SMKACVSETL SLLGEHFGQL LELALTREVQ ALVRKIDTSD NIYITESTTG NLFGLTQEGA PLCRIIAKEG GVVALFKVCR QDSFRCLYPQ ALRTLASICC VEEGVHQLEK VDGILCLADI LTDESHSEAT RAEAAAVVAQ VTSPHLSFTQ HLTSFLENME EIVTALIKLC QEASSGEVFL LASAALANIT FFDKMACEML LQLNAIRVLL EACGDKQRVD TPYTRDQIVT ILANMSVLEQ CGSDIIQENG VQLIMGMLSE KPRSGTPAEV AACERVQQKA AVTLARLCRD PDVAQEAVRL SCMSRLIELC RSPSERNSSD AVLVACLAAL RRLAGVCPEG LQDSDFQQLV QPRLVDSFLL CSNMEESFV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium.
  • 基因功能参考文献：
    1. Excess mINSC drives symmetric cell division, more stem cells and enhanced mammary outgrowth. PMID: 26440891
    2. Data (including data from studies using embryonic stem cell line) suggest that expression of Insc (inscuteable cell cycle protein) is up-regulated by c-Rel in cell differentiation; minimum transcriptional regulatory element (354 bases) was identified. PMID: 26694615
    3. Insc controls directional migration via noncanonical G protein signaling, in which Gbetagamma-free Galphai-GDP, a product from Galphai-GTP released after receptor activation, plays a central role. PMID: 23891662
    4. Mouse inscuteable induces apical-basal spindle orientation, which affects the rate of indirect neurogenesis, a process where progenitors give rise to basal progenitors, which in turn divide symmetrically into two differentiating neurons. PMID: 22017987
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cell cortex.
  • 组织特异性：
    Expressed in brain, kidney, liver, testis and skin.
  • 数据库链接：

    KEGG: mmu:233752

    STRING: 10090.ENSMUSP00000112682

    UniGene: Mm.83037