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  4. Recombinant Mouse Protein phosphatase 1 regulatory inhibitor subunit 16B (Ppp1r16b)

Recombinant Mouse Protein phosphatase 1 regulatory inhibitor subunit 16B (Ppp1r16b)

  • 中文名称：
    小鼠Ppp1r16b重组蛋白
  • 货号：
    CSB-YP848708MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ppp1r16b重组蛋白
  • 货号：
    CSB-EP848708MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ppp1r16b重组蛋白
  • 货号：
    CSB-EP848708MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ppp1r16b重组蛋白
  • 货号：
    CSB-BP848708MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ppp1r16b重组蛋白
  • 货号：
    CSB-MP848708MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ppp1r16b
  • Uniprot No.：
  • 别名：
    Ppp1r16b; Protein phosphatase 1 regulatory inhibitor subunit 16B; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-565
  • 氨基酸序列
    MASHVDLLTE LQLLEKVPTL ERLRAAQKRR AQQLKKWAQY EQDLLHRKRK HERKRSTGGR RKKVSFEASV ALLEASLRND AEEVRYFLKN KVSPDLCNED GLTALHQCCI DNFEEIVKLL LSHGANVNAK DNELWTPLHA AATCGHINLV KILVQYGADL LAVNSDGNMP YDLCEDEPTL DVIETCMAYQ GITQEKINEM RAAPEQKMIS DIHCMIAAGQ DLDWIDGQGA TLLHIAGANG YLRAAELLLD HGVRVDVKDW DGWEPLHAAA FWGQMPMAEL LVSHGASLSA RTSMDEMPID LCEEEEFKVL LLELKHKHDV IMKSQLRHKS SLSRRTSSAG SRGKVVRRAS LSDRTNLYRK EYEGEAILWQ QRSAAEDQRT STYNGDIRET RTDQENKDPN PRLEKPVLLS EFSTKISRGE LDGPVENGLR APVSTYQYAL ANGDIWKMHE MPDYSMAYGN PGVADVPPPW SGFKEQSPQT LLELKRQRAA AKLLSHPFLS THLGSSVARS GESSSEGKAP LIGGRTSPYS SNGTSVYYTV TSGDPPLLKF KAPMEEMEEK VHGCC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage. Involved in the regulation of the PI3K/AKT signaling pathway. Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the dephosphorylation of EEF1A1.
  • 基因功能参考文献：
    1. TIMAP is suppressed by TGFbeta via HDAC3-associated Smad signaling. PMID: 27709267
    2. These data confirmed the barrier-protective role of TIMAP PMID: 21907835
    3. mRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain. PMID: 12638124
  • 亚细胞定位：
    Cell membrane. Cell membrane; Lipid-anchor. Nucleus. Cell projection.
  • 数据库链接：

    KEGG: mmu:228852

    STRING: 10090.ENSMUSP00000039540

    UniGene: Mm.150540