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  4. Recombinant Mouse Prothyroliberin (Trh)

Recombinant Mouse Prothyroliberin (Trh)

  • 货号：
    CSB-YP733822MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP733822MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP733822MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP733822MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP733822MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trh
  • Uniprot No.：
  • 别名：
    Trh; Pro-thyrotropin-releasing hormone; Pro-TRH; Prothyroliberin) [Cleaved into: Thyrotropin-releasing hormone; TRH; Protirelin; TSH-releasing factor; Thyroliberin; Thyrotropin-releasing factor; TRF)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-256
  • 氨基酸序列
    LLEAAQ EEGAVTPDLP GLEKVQVRPE RRFLRKDLQR VRGDLGAALD SWITKRQHPG KREEKEEDVE AEERGDLGEV GAWRPHKRQH PGRRANQDKD SWSDEGDSDW LPPSWLPDFF LDSWFSDAPQ VKRQHPGRRS FPWMESDVTK RQHPGRRFID PELQRSWEET EGEEGGLMPE KRQHPGKRAV GHPCGPQGIC GQTGLLQLLG DLSRGQETLA KQTPQLEAWV REPLEE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.
  • 基因功能参考文献：
    1. co-regulation of the enzyme glutaminyl cyclase and its substrate TRH was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta deposits PMID: 25446989
    2. RXRA and RXRB display specific roles in modulating T3-dependent regulation of thyrotropin releasing hormone. PMID: 23896434
    3. Reversal of hypothyroidism in female patient after treatment with thyrotropin releasing hormone. PMID: 6432893
    4. Data suggest that expression of TRH is up-regulated by CREM (cAMP responsive element modulator protein) in hypothalamus; however, regulation of TRH by triiodothyronine appears independent of CREM or CREB (cAMP responsive element binding protein). PMID: 23000398
    5. Thyrotropin-releasing hormone altered the basal expression of the TSHbeta gene and the responsiveness of the gene to thyroid hormone. PMID: 22792320
    6. Klf4 plays a key role in the maturation of TRH expression in hypothalamic neurons. PMID: 21182892
    7. Data demonstrate that the distribution of hypophysiotropic TRH neurons in mice is vastly different from the pattern in rats, with a dominant occurrence of these neurosecretory cells in the compact part and adjacent regions at the mid-level of the PVN. PMID: 20737594
    8. These demonstrations of PPARgamma effects on hypothalamic Trh transcription in vivo consolidate the role of the TRH neuron as a central integrator of energy homeostasis. PMID: 19900503
    9. study provides functional in vivo data showing that both thyroid hormone receptor beta1 and beta2 isoforms have specific roles in regulating thyrotropin releasing hormone transcription PMID: 14726446
    10. Detailed analysis of TRH-knockout mice might provide insight into physiological significance of endogenous TRH. Present review focuses on phenotypic findings of mice deficient in TRH. PMID: 14751031
    11. Expression of thyrotorpin receptors 1 and 2, key elements in TRH regulation, was modified by thyroid status in the hypothalamus but not in the cortex. PMID: 15225659
    12. TRH is absolutely required for both TSH and TH synthesis but is not necessary for thyrotroph cell development PMID: 16339138
    13. TRH is not essential for pregnancy and lactation, but is required for full function of the lactotrophs, and the PRL mRNA level in the pituitary is regulated by TRH, both directly and indirectly via thyroid hormone PMID: 16484326
    14. Trh is expressed dynamically and specifically in the developing mouse definitive endoderm from E7.0 to E8.5 PMID: 17849455
    15. TRH neurons in the hypothalamic paraventricular nucleus suggest that CB1 endocannabinoids may influence both excitatory and inhibitory inputs of these neurons. PMID: 18818298
    16. provide evidence in mice that TSH participates in this photoperiodic signal transduction PMID: 19015516
    17. Results identify TRH as a modulator of orexin neuron firing in the hypothalamus, and suggest that orexin cell excitation may contribute to the arousal-enhancing actions of TRH. PMID: 19204048
    18. TRH modulates behavioral arousal, in part, through the Hcrt system. PMID: 19321767
    19. Direct receptor-mediated excitation of histaminergic tuberomamillary neurons by TRH demands activation of nonselective cation channels as well as electrogenic sodium/divalent calcium ion exchange. PMID: 19357273
    20. Released TRH is inactivated by an ectopeptidase, pyroglutamyl aminopeptidase II (PPII). Acute administration of alcohol modulates pyroglutamyl amino peptidase II activity and mRNA levels in rat limbic regions. PMID: 15707699
    21. There is considerable evidence linking alcohol consumption, sedation, and thyrotropin-releasing hormone (TRH) in the brain septum. PMID: 15240370

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TRH family
  • 组织特异性：
    Specifically expressed in hypothalamus and testis.
  • 数据库链接：

    KEGG: mmu:22044

    STRING: 10090.ENSMUSP00000006046

    UniGene: Mm.1363