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  4. Recombinant Mouse REST corepressor 2 (Rcor2)

Recombinant Mouse REST corepressor 2 (Rcor2)

  • 货号：
    CSB-YP019516MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019516MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019516MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019516MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019516MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rcor2
  • Uniprot No.：
  • 别名：
    Rcor2; REST corepressor 2; M-CoREST
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-523
  • 氨基酸序列
    MPSVMEKPSA GSGILSRSRA KTAPNGGQPH SEDDSSEEEH SHDSMIRVGT NYQAVIPECK PESPARYSNK ELKGMLVWSP NHCVSDAKLD KYIAMAKEKH GYNIEQALGM LLWHKHDVEK SLADLANFTP FPDEWTVEDK VLFEQAFGFH GKCFQRIQQM LPDKVIPSLV KYYYSWKKTR SRTSVMDRQA RRLGGRKDKE DSDELEEGRG AVSEGEPDTG DPKREPLPSR PLNARPGPGK KEVQISQYRH HPLRTRRRPP KGMYLSPEGL TAVSGSPDLA NLTLRGLDSQ LISLKRQVQS MKQTNSSLRQ ALEGGIDPLR PPEANTKFNS RWTTDEQLLA VQAIRRYGKD FGAIAEVIGN KTLTQVKTFF VSYRRRFNLE EVLQEWEAEQ DGAPAAPVPT EEARRGAPVP ATALEEDDEV QITSVSTSVP RSVPPAPPPP PPPTSLSQPP PLLRPPLPTA PTLLRQPPPL QQGRFLQPRL APNQPPPPLI RPALAASRHS ARPGPQPPPT LVGAPLEPPA PSL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a component of a corepressor complex that represses transcription.
  • 基因功能参考文献：
    1. An INSM1/RCOR1/2 complex controls the balance of proliferation and differentiation during brain development. PMID: 28049845
    2. CoREST1 promotes tumorigenesis in a breast cancer model at least in part through regulation of gene expression patterns in tumor cells. PMID: 25793264
    3. p120-catenin regulates REST and CoREST and modulates mouse embryonic stem cell differentiation. PMID: 25074806
    4. miR-22 and miR-124 are expressed in the cortical wall where they target components of the CoREST/REST transcriptional repressor complex, thereby regulating doublecortin transcription in migrating neurons. PMID: 24794437
    5. The results of this study suggested that Rcor2 downregulation in astrocytes induces inflammation. PMID: 25051986
    6. The loss of CoREST function perturbs the dynamics of neuronal precursor cell populations, transiently increasing the fraction of cells remaining in progenitor states. PMID: 21878487
    7. Ectopic expression of Rcor2 in both mouse and human somatic cells effectively substituted the requirement for exogenous Sox2 expression in somatic cell reprogramming. PMID: 21433225
    8. ES cells specific Rcor2-LSD1 complex not Rcor1-LSD1 complex regulates ESC property. PMID: 21433225
    9. In neural stem cells, identified a larger number of CoREST (1,820) compared with REST (322) target genes. The majority of these CoREST targets do not contain known RE1 motifs. PMID: 20823235
    10. REST and CoREST modulate not only neuronal but also glial lineage elaboration PMID: 19888342
    11. The differential deployment of REST and CoREST is an important regulatory mechanism that mediates neuronal subtype specification by modulating specific gene networks responsible for inducing and maintaining neuronal subtype identity. PMID: 19997604

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CoREST family
  • 组织特异性：
    Predominantly, but not exclusively, expressed in neural tissue. Strongly expressed in neural domains of the developing brain of the developing mouse CNS.
  • 数据库链接：

    KEGG: mmu:104383

    STRING: 10090.ENSMUSP00000108996

    UniGene: Mm.283859