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  4. Recombinant Mouse RILP-like protein 1 (Rilpl1)

Recombinant Mouse RILP-like protein 1 (Rilpl1)

  • 中文名称：
    小鼠Rilpl1重组蛋白
  • 货号：
    CSB-YP872852MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rilpl1重组蛋白
  • 货号：
    CSB-EP872852MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rilpl1重组蛋白
  • 货号：
    CSB-EP872852MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rilpl1重组蛋白
  • 货号：
    CSB-BP872852MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rilpl1重组蛋白
  • 货号：
    CSB-MP872852MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rilpl1
  • Uniprot No.：
  • 别名：
    Rilpl1; MNCb-2440; RILP-like protein 1; Rab-interacting lysosomal-like protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-406
  • 氨基酸序列
    MEEPLGSPPA ALSALEKNVA ELTVMDVYDI ASLVGHEFER VIDQHGCESI ARLMPKVVRV LEILEVLVSR HHVAPELDEL RLELDRLRVE RMDRIEKERK HQKELELVED VWRGEAQDLL SQIAQLQEEN KQLMTNLNHK DVGFSEEEFQ KQEGMSERER QVMKRLKEVV DKQRDELRAK DRELGLKNED VEALQQQQTR LMKINHDLRH RVTVVEAQGK ALIEQKVELE ADLQTKEQEM GSLRAELGKL RERLQGEHSQ NGEEEEAEIQ PQPDGEESIS DAEKAALDLK DPNRPRFTLQ ELRDVLHERN ELKSKVFLLQ EELAYYKSEE IEEENRIPQP PPITHPRTSP QPESGIKRLF SFFSRDKKRL ANTQRPTHIH ESFGQWAITQ RDDGYTEQGQ EALQHL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH. Does not regulate lysosomal morphology and distribution. Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis.
  • 基因功能参考文献：
    1. The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content by promoting protein removal from the primary cilium. PMID: 23264467
    2. In intact mice, virally delivered GOSPEL selectively diminishes NMDA neurotoxicity. Thus, GOSPEL may physiologically regulate the viability of neurons and other cells. PMID: 19607794
  • 亚细胞定位：
    Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
  • 蛋白家族：
    RILPL family
  • 数据库链接：

    KEGG: mmu:75695

    STRING: 10090.ENSMUSP00000050014

    UniGene: Mm.41180