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  4. Recombinant Mouse RNA binding protein fox-1 homolog 2 (Rbfox2)

Recombinant Mouse RNA binding protein fox-1 homolog 2 (Rbfox2)

  • 货号：
    CSB-YP804837MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP804837MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP804837MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP804837MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP804837MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rbfox2
  • Uniprot No.：
  • 别名：
    Rbfox2; Fox2; Fxh; Hrnbp2; Rbm9; RNA binding protein fox-1 homolog 2; Fox-1 homolog B; Fox-1 homolog Fxh; Hexaribonucleotide-binding protein 2; RNA-binding motif protein 9; RNA-binding protein 9
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-449
  • 氨基酸序列
    MAEGGQAQQQ PPQLGPGAAA RGMKRESEVE LPVPGAGADG PEPGLSKRPR TEEAADGGMQ NEPLTPGYHG FPARDGQGNQ EPTTTPDAMV QPFTTIPFPP PPQNGIPTEY GVPHTQDYAG QTSEHNLTLY GSTQPHGEQS SNSPSNQNGS LTQTEGGAQT DGQQSQTQSS ENSESKSTPK RLHVSNIPFR FRDPDLRQMF GQFGKILDVE IIFNERGSKG FGFVTFENSA DADRAREKLH GTVVEGRKIE VNNATARVMT NKKMVTPYAN GWKLSPVVGA VYGPELYAAS SFQADVSLGN EAAVPLSGRG GINTYIPLIS LPLVPGFPYP TAATTAAAFR GAHLRGRGRT VYGAVRAVPP TAIPAYPGVV YQDGFYGADL YGGYAAYRYA QPATATAATA AAAAAAAYSD GYGRVYTADP YHALAPAASY GVGAVASLYR GGYSRFAPY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha.
  • 基因功能参考文献：
    1. These data reveal an alternative splicing program activated by Rbfox2 in the endothelium on recruitment of platelets and macrophages and demonstrate its relevance in transcriptional responses during flow-driven vascular inflammation. PMID: 29293084
    2. This study demonstrated that the Rbfox2 represses e18a inclusion during pre-mRNA splicing of CaV2.2, limiting the size of CaV2.2 currents early in development in certain neuronal populations. PMID: 29067356
    3. RBFOX2 dysregulation by dominant-negative RBFOX2 is an early pathogenic event in diabetic hearts. PMID: 27239029
    4. RBFox2 interactis with chromatin in a nascent RNA-dependent manner. RBFox2 inactivation eradicates PRC2 targeting on the majority of bivalent gene promoters and leads to transcriptional de-repression. PMID: 27211866
    5. A classic nuclear localization signal at the N terminus that regulates the subcellular localization of Rbfox2 isoforms during differentiation of the mouse epithelial and embryonic stem cells lines has been identified. PMID: 27859055
    6. Gain- and loss-of-function experiments demonstrated that Rbfox1 and Rbfox2 cooperate in promoting Mef2D splicing and subsequent myogenesis. PMID: 25609712
    7. Results show that the conserved Rbfox2 RNA binding protein regulates 30% of the splicing transitions observed during myogenesis and is required for the specific step of myoblast fusion. PMID: 25087874
    8. an unexpectedly broad and multilayer regulatory network controlled by Rbfox2 and offer an explanation for how autoregulatory splicing networks are tuned PMID: 24637117
    9. During an EMT, Rbfox2-regulated splicing shifts from epithelial-to mesenchymal-specific events. PMID: 23435423
    10. Rbfox2 protein controls a post-transcriptional program required for proper brain development. PMID: 22357600
    11. the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism PMID: 21747913
    12. The present study provides evidence that alternative neuronal nPTB and Fox-1/Fox-2 isoforms are also produced in lenses PMID: 21714144
    13. Fox-1 and Fox-2 isoforms specifically activate splicing of neuronally regulated exons, which requires UGCAUG enhancer elements PMID: 16260614

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Detected in brain neurons (at protein level). Detected in heart, brain, embryo, lung, liver, kidney and ovary.
  • 数据库链接：

    KEGG: mmu:93686

    STRING: 10090.ENSMUSP00000130739

    UniGene: Mm.202774