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  4. Recombinant Mouse Rab-interacting lysosomal protein (Rilp)

Recombinant Mouse Rab-interacting lysosomal protein (Rilp)

  • 中文名称：
    小鼠Rilp重组蛋白
  • 货号：
    CSB-YP705858MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rilp重组蛋白
  • 货号：
    CSB-EP705858MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rilp重组蛋白
  • 货号：
    CSB-EP705858MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rilp重组蛋白
  • 货号：
    CSB-BP705858MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rilp重组蛋白
  • 货号：
    CSB-MP705858MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rilp
  • Uniprot No.：
  • 别名：
    Rilp; Rab-interacting lysosomal protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-369
  • 氨基酸序列
    MEPRRAAPRL PSQASSSVGA GSAAELVYHL AGALGTELQG LARRFGPDAA AGLVPLVVRA LELLEKAAVG PAPDSLQVSA QQAEVELRRL REENQRLRQE LGSGPQEERA LLRQLKEVTD RQRDELRAHN RDLQRRSQET EALQEQLQRL LLINSELRHK LAAVQTQLRA AQDRERERQI AQDGSSQLAK EQSLEPDAAT SDDPVDTQKQ PGNLPEAVQC GFSREELKQI LQERNELKAN VFLLKEELAY FQRELLTDHR VPGLLLEAMK VAVKKQRRKI KAKMLGTPEE AESSEDEDGS WLLLSNDKED VPLVPESRIQ NFFGLWYRGE TEAPEAETSN PASSSLQKGE ETPQQPHLQP VNSPPAPNS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.
  • 基因功能参考文献：
    1. The up-regulation of Rab11, Rab7, or RILP, but not its truncated form RILP-C33, rescued LAMP2A-defective trafficking in cystinosis, whereas dominant-negative Rab11 or Rab7 impaired LAMP2A trafficking. PMID: 28465352
    2. A new mechanism by which the dynein-dynactin motor complex recognizes Mreg on mature melanosomes is revealed through interaction with RILP and is involved in the centripetal movement of melanosomes. PMID: 22275436
    3. CD63, but not RILP, is recruited to the phagosomes in macrophages expressing the dominant negative form of Rab7. PMID: 20236428
  • 亚细胞定位：
    Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, phagosome membrane.
  • 数据库链接：

    KEGG: mmu:280408

    STRING: 10090.ENSMUSP00000037238

    UniGene: Mm.41416