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  4. Recombinant Mouse Ras association domain-containing protein 1 (Rassf1)

Recombinant Mouse Ras association domain-containing protein 1 (Rassf1)

  • 中文名称：
    小鼠Rassf1重组蛋白
  • 货号：
    CSB-YP860823MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rassf1重组蛋白
  • 货号：
    CSB-EP860823MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rassf1重组蛋白
  • 货号：
    CSB-EP860823MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rassf1重组蛋白
  • 货号：
    CSB-BP860823MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rassf1重组蛋白
  • 货号：
    CSB-MP860823MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rassf1; Ras association domain-containing protein 1; Protein 123F2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-340
  • 氨基酸序列
    SAEPELIEL RELAPSGRIG PGRTRLERAN ALRIAPGTTR NPSQQHVPGR GHRFQPAGPT THTWCDLCGD FIWGVVRKGL QCAHCKFTCH YRCRALVCLD CCGPRDLGWD SALERDTNVD EAVERETPDL SQAETEQKIK DYNGQINSNL FMSLNKDGSY TGFIKVQLKL VRPVSVPSSK KPPSLQDARR GTGRSTAVKR RTSFYLPKDA IKHLHVLSRT RAREVIEALL RKFMVVDDPR KFALFERTER HGQVYLRKLS DDEQPLKLRL LAGPSEKALS FVLKENDSGE VNWDAFSMPE LHNFLRILQR EEEEHLRQIL QKYSRCRQKI QEALHACPLG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
  • 基因功能参考文献：
    1. RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP and p73 binding to differentiation related genes.RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73. PMID: 29382819
    2. beta-catenin was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1, isoform A (RASSF1A) inactivation in liver metastases. PMID: 27765918
    3. RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB and is essential for protection against inflammation-induced injury. PMID: 24146755
    4. nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis. PMID: 24579805
    5. Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis. PMID: 22710434
    6. Data show that methylation of CCND-2, p16, RAR-beta and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens. PMID: 19618401
    7. Deletion of this gene increases cancer susceptibility in mice. PMID: 15665283
    8. Rassf1A acts as a tumor suppressor gene. PMID: 16135822
    9. cooperation between inactivation of Rassf1a and Apc resulting in accelerated intestinal tumourigenesis. PMID: 18391979
    10. RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt. PMID: 19223555
    11. data establish RASSF1A as a novel inhibitor of cardiac hypertrophy by modulating the extracellular regulated kinase 1/2 pathway. PMID: 19652091

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  • 亚细胞定位：
    [Isoform A]: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.; [Isoform C]: Nucleus.
  • 数据库链接：

    KEGG: mmu:56289

    STRING: 10090.ENSMUSP00000091301

    UniGene: Mm.12091