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  4. Recombinant Mouse Ras-related protein R-Ras (Rras)

Recombinant Mouse Ras-related protein R-Ras (Rras)

  • 货号：
    CSB-YP020513MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP020513MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP020513MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP020513MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP020513MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rras; Ras-related protein R-Ras; p23
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-215
  • 氨基酸序列
    MSSGAASGTG RGRPRGGGPG PRDPPPGETH KLVVVGGGGV GKSALTIQFI QSYFVSDYDP TIEDSYTKIC TVDGIPARLD ILDTAGQEEF GAMREQYMRA GNGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPIVLV GNKADLENQR QVLRSEASSF SASHHMTYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP SPPSAPRKKD GGCPC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.
  • 基因功能参考文献：
    1. Taken together, despite having reduced number of conventional DC's in the R-Ras KO mice and low expression of CD80 on DC's, the R-Ras KO mice are capable of mounting papain-induced IgE responses comparable to that of the WT mice. PMID: 28497586
    2. R-Ras is pro-tumourigenic in the mouse DMBA/TPA tumour model and important for the inflammatory response to DMBA/TPA treatment. PMID: 26133397
    3. the data provide evidence for a role of R-Ras in the mediation of chemokine receptor-mediated signaling in migrating T cells in the high endothelial venules. PMID: 26710069
    4. Study reveals a novel role for the R-Ras GTPase in the brain by demonstrating its requirement for high-frequency stimulation long-term potentiation in the CA1 hippocampus in adult mice, as well as contextual discrimination PMID: 25043327
    5. a novel role for R-Ras in promoting autoimmunity through negative regulation of natural regulatory T cell numbers by inhibiting the development of MHCII(low) DC with tolerogenic potential. PMID: 24771856
    6. Geranylgeranylation was required for membrane anchorage of Rras, whereas palmitoylation was required for exit from the Golgi in post-Golgi vesicle membranes and trafficking to the plasma membrane. PMID: 22751447
    7. These findings identify R-Ras as a critical regulator of vessel integrity and function during tumor vascularization. PMID: 22897853
    8. First demonstration of a role for R-Ras in cell-mediated immunity and further expand on the complexity of small G-protein signaling in dendritic cells. PMID: 22174156
    9. R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization. PMID: 21572048
    10. R-Ras is a small GTPase of the Ras family that regulates cell survival and integrin activity and is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. [R-ras] PMID: 16286923
    11. Data suggest that R-Ras and TC-21 play a role in facilitating branching and growth in early ureteric bud development, whereas H-Ras might favor cell migration and elongation of tubules, events that occur later in development. PMID: 16467383
    12. Rnd2 bound to Plexin-D1 in cortical neurons, and Sema3E/Plexin-D1-induced inhibition of axon outgrowth of cortical neurons required Rnd2 and down-regulation of R-Ras activity. PMID: 19136556

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 数据库链接：

    KEGG: mmu:20130

    STRING: 10090.ENSMUSP00000042150

    UniGene: Mm.389894