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  4. Recombinant Mouse RecQ-mediated genome instability protein 1 (Rmi1)

Recombinant Mouse RecQ-mediated genome instability protein 1 (Rmi1)

  • 中文名称：
    小鼠Rmi1重组蛋白
  • 货号：
    CSB-YP887521MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rmi1重组蛋白
  • 货号：
    CSB-EP887521MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rmi1重组蛋白
  • 货号：
    CSB-EP887521MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rmi1重组蛋白
  • 货号：
    CSB-BP887521MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rmi1重组蛋白
  • 货号：
    CSB-MP887521MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rmi1
  • Uniprot No.：
  • 别名：
    Rmi1; RecQ-mediated genome instability protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-616
  • 氨基酸序列
    MSVASAVLRV ETWLLATWHV KVPPMWLEAC VNWIQEENNN ATLSQAQINK QVLEQWLLTD LRDLEHPLLP DDILELPKGE LNGFYALQIN SLVDVSQPAY SQIQKLRGKN TTNDLVSAET QSTPKPWEVR PSRMLMLQLT DGVTHIQGME YQSIPALHSG LPPGTKILVR GCILFRLGVL LLKPENVKVL GGEVDGLSEE NAQEKVLARL IGELDPTVPV IPNNSIHNVP KVSGGLDAVL GPSDEELLAS LDESEESAAN NDVAMERSCF STGTSSNTTP TNPSGFEPGC NISSRPKEKP PNQPTHFTDG EFDDFSLEEA LLLEETVQKE QMETKASQPL TLKENTGKCM EIFSHKPSSL NHTALIHKQG NSNFDEKTSE QMIHEDKFFD CASTRNHHKR FSAHDFTNDS KISEVDDAAQ QTLSSSNVHC LRNKILNRKL DLSEKSSQIS KENGHPFQAC SSRSFENNTY LSIGMDLHSP PFIYLSVLMA RKPKEVTTVT VKAFIVTLTG NLSSSGGFWG VTAKVSDGTA YLDVDFIDEI LTSMIGYSVP EMKQLRKDPL KYKTFLEGLQ KCQRDLIDLC CLMTISYDPS SCKGVVLELQ DVGMEHVENL KKRLNK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
  • 基因功能参考文献：
    1. results demonstrate the importance of RMI1 in maintaining genome integrity and normal embryonic development PMID: 23900276
    2. Glucose regulates RMI1 expression through the E2F pathways in adipose cells. PMID: 21432623
    3. These results demonstrated a dual-role of RMI1 in embryonic development and tumor suppression. PMID: 21229605
    4. results suggest that the regulation of energy balance by RMI1 is attributable to the regulation of food intake and E2F8 expression in adipose tissue. PMID: 20050919
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    RMI1 family
  • 数据库链接：

    KEGG: mmu:74386

    STRING: 10090.ENSMUSP00000041035

    UniGene: Mm.85289