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  4. Recombinant Mouse Receptor tyrosine-protein kinase erbB-3 (Erbb3), partial

Recombinant Mouse Receptor tyrosine-protein kinase erbB-3 (Erbb3), partial

  • 货号：
    CSB-YP736823MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP736823MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP736823MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP736823MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP736823MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Erbb3Receptor tyrosine-protein kinase erbB-3; EC 2.7.10.1; Glial growth factor receptor; Proto-oncogene-like protein c-ErbB-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.
  • 基因功能参考文献：
    1. Result suggest the potential for a paracrine signalling network whereby basal cells secrete neuregulin 1 (Nrg1), which acts on luminal cells via Erbb3 and Erbb4 receptors. PMID: 27782124
    2. The s demonstrate that ErbB3 signaling is required for the embryonic development of the enteric nervous system. PMID: 29078343
    3. These studies demonstrate that ErbB3, like ErbB4, enhances lactogenic expansion and differentiation of the mammary gland during pregnancy, through activation of Akt and STAT5A, two targets crucial for lactation. PMID: 28886748
    4. nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells PMID: 27017927
    5. ERBB3 is required for wound healing and for the progression of skin tumors in mice. PMID: 26194695
    6. The expression of ERBB3 in combination with ERBB4 significantly amplifies proliferation of lymphocytes upon ligand stimulation. PMID: 26745281
    7. Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt pathway and promoting erbB2-driven mammary/breast tumorigenesis. PMID: 26261492
    8. Suggest that ERBB3 may promote hepatocellular carcinoma through STAT3 activation. PMID: 26492920
    9. ERBB3 is crucial for the proliferation of Bergmann glia in the developing cerebellum. PMID: 25564653
    10. ErbB3 plays a key role in migration, as well as in myelination, in mouse Schwann lineage cells. PMID: 25204498
    11. Knock-down of Erbb3 with siRNA during early differentiation inhibits cardiomyogenesis in embryonic stem cells. PMID: 24364879
    12. PIK3CA(H1047R)-driven tumor growth and PI3K signaling can occur independently of ErbB3 receptor tyrosine kinases. PMID: 23633485
    13. downregulation of ErbB3 induced by Wnt3a contributes to Wnt3a-induced early osteoblast differentiation of Mesenchymal stem cells through increased canonical Wnt/beta-catenin signaling and decreased Src signaling. PMID: 22274864
    14. findings indicate that although ErbB3-associated PI3K activity is critical for mammary development, it is dispensable for ErbB2-induced mammary tumor progression PMID: 22665265
    15. our findings suggest that ErbB3 promotes HER2-induced changes in the breast epithelium before, during, and after tumor formation. PMID: 22461506
    16. Bone marrow-derived mesenchymal stem cells up-regulate skeletal muscle acetylcholine receptor delta subunit through NRG/ErbB3-mediated mitogen-activated protein kinase pathway. PMID: 22376253
    17. ErbB3 regulates the balance of differentiated breast epithelial cell types. PMID: 22178756
    18. Measurements in breast tumor samples showed correlations between HER3 phosphorylation and receptor interactions PMID: 21297994
    19. Results demonstrate that ErbB3, in addition to ErbB4, is a receptor for neuregulin-1beta in the adult mouse heart. PMID: 20672328
    20. results show that ZNF217 regulates ErbB3 expression PMID: 20661224
    21. Post-transcriptional mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors. PMID: 20628057
    22. Results suggest that although both Lrig1 and Lrig3 can interact with ErbB receptors in vitro, modulation of Neuregulin signaling is unlikely to contribute to Lrig3-dependent processes of inner ear morphogenesis. PMID: 20126551
    23. ErbB3 may participate in tooth morphogenesis PMID: 12112465
    24. The co-expression of wt rat neu/ErbB2 transgene and mouse ErbB3, with physical and functional interactions between these two species of RTK receptors, was demonstrated in mouse mammary tumors. PMID: 16168116
    25. The Asn(418)-linked N-glycan in ErbB3 plays an essential role in regulating receptor heterodimerization with ErbB2 and might have an effect on transforming activity. PMID: 17332320
    26. p45-sErbB3 may mediate the bidirectional interactions between prostate cancer cells and bone via osteonectin PMID: 17638862
    27. observations establish that p45-sErbB3 is a structurally and functionally unique gene product of ErbB3 and suggest that p45-sErbB3 is likely one of the factors involved in the osteoblastic bone metastases of prostate cancer PMID: 18490922
    28. inhibition of HER3 may be more clinically relevant than inhibition of EGFR in HER2-amplified breast cancer and adding pertuzumab to trasteguzumab may augment therapeutic benefit by blocking HER2/HER3 signaling PMID: 18632642
    29. Oligodendrocytes lacking both ErbB3 and ErbB4 are incapable of transmitting signals from neuregulins. These double mutant oligodendrocytes survive and myelinate CNS axons in vivo, in marked contrast to double-mutant Schwann cells. PMID: 18760695
    30. findings highlight the importance of the mutated residue for ERBB3 receptor function and activation.Linkage analysis, sequencing, and complementation testing confirmed that msp1 is a new allele of the receptor tyrosine kinase Erbb3 PMID: 18773073
    31. ErbB3 is required for ductal morphogenesis in the mouse mammary gland. PMID: 19019207
    32. intestine-specific Erbb3 ablation resulted in almost complete absence of intestinal tumors in the ApcMin model of colon cancer PMID: 19690388

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
  • 组织特异性：
    In the muscle, expression localizes to the synaptic sites of muscle fibers.
  • 数据库链接：

    KEGG: mmu:13867

    STRING: 10090.ENSMUSP00000080716

    UniGene: Mm.373043