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Recombinant Mouse Recoverin (Rcvrn)

  • 中文名称：
    小鼠Rcvrn重组蛋白
  • 货号：
    CSB-YP019519MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rcvrn重组蛋白
  • 货号：
    CSB-EP019519MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rcvrn重组蛋白
  • 货号：
    CSB-EP019519MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rcvrn重组蛋白
  • 货号：
    CSB-BP019519MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rcvrn重组蛋白
  • 货号：
    CSB-MP019519MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rcvrn
  • Uniprot No.：
  • 别名：
    Rcvrn; Rcv1; Recoverin; 23 kDa photoreceptor cell-specific protein; Cancer-associated retinopathy protein; Protein CAR
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-202
  • 氨基酸序列
    GNSKSGALS KEILEELQLN TKFTEEELSA WYQSFLKECP SGRITRQEFE SIYSKFFPDS DPKAYAQHVF RSFDANSDGT LDFKEYVIAL HMTTAGKPTQ KLEWAFSLYD VDGNGTISKN EVLEIVMAIF KMIKPEDVKL LPDDENTPEK RAEKIWAFFG KKEDDKLTEE EFIEGTLANK EILRLIQFEP QKVKERIKEK KQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Modulates light sensitivity of cone photoreceptor in dark and dim conditions. In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin. Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells. Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light.
  • 基因功能参考文献：
    1. Rods and cones share the same isoforms of recoverin and GRK1, and photoactivation also triggers a calcium decline in cones PMID: 25673692
    2. recoverin may modulate the decay of light-activated PDE*, which may be responsible for the quickening of response recovery in background light. PMID: 23136436
    3. High anti-recoverin antibody levels were achieved in two mouse models, accompanied by significantly reduced scotopic and photopic responses on the electroretinograms. PMID: 21031137
    4. This is the first demonstration in an intact rod that light accelerates Rh* inactivation and that the Ca(2+)-binding protein recoverin may be required for the light-dependent modulation of Rh* lifetime. PMID: 20107049
    5. recoverin undergoes light-dependent intracellular translocation in mouse rod photoreceptors PMID: 15961391

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  • 亚细胞定位：
    Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Photoreceptor outer segment membrane; Lipid-anchor; Cytoplasmic side. Perikaryon.
  • 蛋白家族：
    Recoverin family
  • 组织特异性：
    Expressed in rod photoreceptors in the retina (at protein level).
  • 数据库链接：

    KEGG: mmu:19674

    STRING: 10090.ENSMUSP00000021290

    UniGene: Mm.439726