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  4. Recombinant Mouse Regulator of G-protein signaling 4 (Rgs4)

Recombinant Mouse Regulator of G-protein signaling 4 (Rgs4)

  • 货号：
    CSB-YP019656MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019656MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019656MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019656MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019656MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rgs4
  • Uniprot No.：
  • 别名：
    Rgs4; Regulator of G-protein signaling 4; RGS4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-205
  • 氨基酸序列
    MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHSSSHS KKDKVVTCQR VSQEEVKKWA ESLENLIHHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLQPTITCFD EAQKKIFNLM ERDSYRRFLK SRFYLDLTNP SSCGAEKQKG AKSSADCTSL VSQCA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
  • 基因功能参考文献：
    1. The nucleus-accumbens-specific knockdown of RGS4 significantly increased the behaviors associated with morphine and did so by phosphorylation of the GluR1 (Ser831) and NR2A (Tyr1325) glutamate receptors in the NAc. PMID: 29754475
    2. Study investigated whether RGS4 could participate in signalling pathways to regulate neurotropic events. These observations suggest that RGS4 is implicated in opioid dependent neuronal differentiation and neurite outgrowth via a "non-canonical" signaling pathway regulating STAT5B-directed responses. PMID: 28219718
    3. These results provide support for the hypothesis that increasing RGS4 expression and/or function could be a viable therapeutic strategy for asthma. PMID: 28853915
    4. RGS4 in the paraventricular nucleus regulates blood corticosteroid-related GABAB receptor signaling during the acute stress response. PMID: 26926565
    5. Thus, RGS4 expression, specific to renal vascular smooth muscle cells, inhibits angiotensin II-mediated cytokine signaling and macrophage recruitment during reperfusion, distinct from vasomotor regulation. PMID: 25469849
    6. Spinal RGS4 inhibited the endogenous or exogenous OR-mediated antinociceptive effect in the formalin pain test. PMID: 25695583
    7. RGS6-Gbeta5, but not RGS4, is the primary RGS modulator of parasympathetic HR regulation and SAN M2R-IKACh signaling in mice. PMID: 24318880
    8. dramatic up-regulation of RGS4 expression in the nucleus accumbens of mice treated with monoamine-directed antidepressants PMID: 23630294
    9. RGS4 expression in mouse embryo is regulated by Lmx1a transcription factor. PMID: 23106268
    10. A novel nitric oxide-RGS4 signal pathway mechanism that couples cardiac vessel growth with myocyte growth and heart size. PMID: 23454748
    11. Findings support the concept that the inhibitory effects of SPL on M3R activity are mediated by RGS4. PMID: 22730439
    12. Rgs4 is expressed in endocrine progenitors of both zebrafish and mouse, and its expression in the mouse pancreatic epithelium is strictly dependent upon Ngn3, and loss of function of Rgs4 results in islet fragmentation in both organisms. PMID: 21911471
    13. RGS4 antagonizes the development of renal dysfunction in response to ischemia reperfusion injury. PMID: 21412219
    14. Data show that absence of the regulatory protein RGS4 rescues several fragile-X related phenotypes, including increased body weight, abnormal synaptic protein expression and inhibition of social behaviors, in FMR1 knockout mice. PMID: 21215802
    15. The RGS protein family may play an important role in the functioning of neural systems that are affected by chronic alcohol abuse; cirrhotic alcoholics have lower expression levels of RGS4 mRNA than controls and non-cirrhotic alcoholics. PMID: 20430014
    16. These findings provide fundamentally novel information concerning the role of RGS4 in the cellular mechanisms underlying the diverse actions of opiate drugs in the nervous system PMID: 19914603
    17. RGS4 is a potent negative regulator of M3R function in pancreatic beta-cells, and may represent a potential target to promote insulin release for therapeutic purposes. PMID: 20385802
    18. In embryonic development transcription of RGS4 occurs in a highly dynamic manner in a small set of peripheral and central neuronal precursors. This expression pattern overlaps extensively with that of the neuronal identity determinant Phox2b PMID: 14627646
    19. Rgs4 regulates vascular endothelial growth factor signaling. PMID: 15548600
    20. RGS4 transgenic mice were resistant to streptozotocin induced cardiac fetal gene induction. PMID: 15561937
    21. Behavioral testing on mutant adults revealed subtle sensorimotor deficits but, so far, supported neither the proposed status of Rgs4 as a schizophrenia susceptibility gene nor a role of Rgs4 in the acute or chronic response to opioids. PMID: 15870291
    22. These results establish RGS4 and RGS5 as in vivo substrates of the mammalian N-end rule pathway and also suggest that the O2-ATE1-UBR1/UBR2 proteolytic circuit plays a role in RGS-regulated G protein signaling in the cardiovascular system. PMID: 16217033
    23. These data suggest that altering RGS4 function will produce a complex neuronal phenotype with cell- and subdomain-specificity in the cerebral cortex. PMID: 16996696
    24. Full length cloning and expression analysis of splice variants of Rgs4 were performed. PMID: 17707117
    25. RGS4 plays important roles in guanylyl cyclase-A -mediated inhibition of cardiac hypertrophy. PMID: 18443239
    26. RGS4 controls the balance between adipose tissue lipolysis and lipogenesis. PMID: 18635652
    27. RGS4 plays an important role in regulating sinus rhythm by inhibiting parasympathetic signaling and I(KACh) activity PMID: 18658048
    28. Multiple splice variant forms of RGS4 and Rgs4 are expressed in human and mouse brain and show differential expression across brain compartments. PMID: 17707117

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  • 组织特异性：
    Expressed at high levels in brain, moderately low levels in heart, and very low levels in lung, liver, and skeletal muscle.
  • 数据库链接：

    KEGG: mmu:19736

    STRING: 10090.ENSMUSP00000027991

    UniGene: Mm.41642