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  4. Recombinant Mouse Regulator of G-protein signaling 5 (Rgs5)

Recombinant Mouse Regulator of G-protein signaling 5 (Rgs5)

  • 货号：
    CSB-YP019657MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019657MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019657MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019657MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019657MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rgs5
  • Uniprot No.：
  • 别名：
    Rgs5; Regulator of G-protein signaling 5; RGS5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-181
  • 氨基酸序列
    MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA HKPSLEEVLQ WRQSLDKLLQ NSYGFASFKS FLKSEFSEEN LEFWVACENY KKIKSPIKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSPRS FDLAQKRIYA LMEKDSLPRF VRSEFYKELI K
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.
  • 基因功能参考文献：
    1. RGS5 is required for hypertension-evoked RhoA activity in vascular smooth muscle. PMID: 29208700
    2. RGS5 is a novel modulator of pathological progression after myocardial infarction that functions NF-kappaB and MAPK signalling. PMID: 29534968
    3. RGS5 inhibits sonic hedgehog function during cortical neurons development. PMID: 28684360
    4. Rgs5 prevents vagal-related bradycardia and atrial tachycardia by negatively regulating the IKA Ach current. PMID: 26961238
    5. RGS5 deletion accelerated development of atherosclerosis and decreased the stability of atherosclerotic plaques partly through activating NF-kappaB and the MEK-ERK1/2 signalling pathways PMID: 25363362
    6. These studies show that RGS5 protects cardiomyocytes against apoptosis during myocardial ischemia-reperfusion injury through inhibiting both JNK1/2 and p38 signaling pathways. PMID: 27021681
    7. Downregulation of RGS5 is an important prerequisite for smooth muscle cell proliferation in vascular injury model. PMID: 26663397
    8. findings highlight a key role of RGS5 at the interface between AngII and PPAR signaling PMID: 26041705
    9. we demonstrate that RGS5 is a critical regulator of GPCR signaling in HSCs and regulates HSC activation and fibrogenesis in liver injury. PMID: 25290689
    10. Collectively, these findings establish RGS5 as a novel determinant of arteriogenesis which shifts G-protein signalling from Galphaq/11-mediated calcium-dependent contraction towards Galpha12/13-mediated Rho kinase-dependent smooth muscle cell activation. PMID: 24972930
    11. Loss of RGS5 promotes airway hyperresponsiveness in the absence of allergic inflammation. PMID: 24666695
    12. study concludes that RGS5 is an endogenous regulator of Hh-mediated signaling PMID: 23637832
    13. Regulator of G-protein signaling 5 controls blood pressure homeostasis and vessel wall remodeling. PMID: 23303165
    14. Rgs5 is an important regulator of arrhythmogenesis in the mouse atrium and that the enhanced susceptibility to atrial tachyarrhythmias in Rgs5(-/-) mice may contribute to abnormalities of atrial repolarization. PMID: 23144791
    15. Rgs5(-/-) induced prolonged repolarization and ventricular tachyarrhythmia, which were closely related to the remodeling of voltage-dependent K(+) currents. PMID: 23079193
    16. Results indicate the role of RGS5 in obesity-associated metabolic dysfunction and insulin sensitivity. PMID: 22272317
    17. Vessel bed-specific changes in regulation of Rgs5 expression occurred during blood vessel maturation. PMID: 21965603
    18. Repetitive beta(2)-agonist use may not only lead to reduced bronchoprotection but also to sensitization of excitation-contraction signaling pathways as a result of reduced RGS5 expression PMID: 21278382
    19. used transgenic mice show that the cardiac constitutive expression of human Rgs5 protects against cardiac hypertrophy and fibrosis by blocking MEK-ERK1/2 signaling, whereas Rgs5-/- mice displayed the opposite phenotype. PMID: 20643937
    20. Rgs5 represents a potential regulator of PDGF and EDG receptor signaling during vascular maturation. PMID: 12514120
    21. These studies establish the use of RGS5 gene expression as a quantitative and robust measure of pericyte coverage of neovasculature. PMID: 18038251
    22. Although rgs5 is upregulated in neoangiogenic processes, the lack of this gene does not appear to have a major effect on pathological vessel formation in the retina, nor does it affect pericyte recruitment or coverage of the abnormal neovessels. PMID: 18212066
    23. Blocking the function or the expression of RGS5 may provide an alternative approach to treat hypertension PMID: 18268011
    24. identification of the regulator of G-protein signalling 5 (Rgs5) as a master gene responsible for the abnormal tumour vascular morphology in mice PMID: 18418378

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  • 亚细胞定位：
    Cytoplasm. Membrane.
  • 组织特异性：
    Expressed in heart and muscle.
  • 数据库链接：

    KEGG: mmu:19737

    STRING: 10090.ENSMUSP00000027997

    UniGene: Mm.20954