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  4. Recombinant Mouse Resistin-like beta (Retnlb)

Recombinant Mouse Resistin-like beta (Retnlb)

  • 中文名称：
    小鼠Retnlb重组蛋白
  • 货号：
    CSB-YP859581MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Retnlb重组蛋白
  • 货号：
    CSB-EP859581MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Retnlb重组蛋白
  • 货号：
    CSB-EP859581MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Retnlb重组蛋白
  • 货号：
    CSB-BP859581MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Retnlb重组蛋白
  • 货号：
    CSB-MP859581MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Retnlb
  • Uniprot No.：
  • 别名：
    Retnlb; Fizz2; Resistin-like beta; Cysteine-rich secreted protein A12-beta; Cysteine-rich secreted protein FIZZ2; RELMbeta
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-105
  • 氨基酸序列
    QCSFESL VDQRIKEALS RQEPKTISCT SVTSSGRLAS CPAGMVVTGC ACGYGCGSWD IRNGNTCHCQ CSVMDWASAR CCRMA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable hormone.
  • 基因功能参考文献：
    1. promotes host-bacterial mutualism by regulating the spatial segregation between the microbiota and the intestinal epithelium PMID: 28973871
    2. The goblet cell-derived RELM-beta drives spontaneous colitis in Muc2-deficient mice by promoting commensal microbial dysbiosis. PMID: 26813339
    3. lack of RELMbeta leads to increased colonic expression of T helper cell type-2 cytokines and IL-17, associated with a reduced ability to maintain intestinal homeostasis PMID: 27397737
    4. These data suggest the contribution of increases in RELMbeta in the gut and Kupffer cells to NASH development, raising the possibility of RELMbeta being a novel therapeutic target for NASH. PMID: 26818807
    5. RELMbeta protein levels were upregulated in Angiotensin II-induced Abdominal aortic aneurysm mice.Immunohistochemical staining revealed abundant expression of RELMbeta in AAA group, with scarce expression with saline treatment animals. PMID: 25479529
    6. findings demonstrate that RELM-beta and goblet cells play an unexpected, yet critical role in recruiting CD4+ T cells to the colon to protect against an enteric pathogen PMID: 26285214
    7. elevated RELM-beta expression in asthmatic airways contributes to airways remodelling at least partly by increasing fibroblast proliferation and differentiation with resulting deposition of extracellular matrix proteins. PMID: 25545115
    8. RELMbeta is abundantly expressed in foam cells within plaques and contributes to atherosclerosis development via lipid accumulation and inflammatory facilitation. PMID: 23702657
    9. a novel role for GC-C signaling in facilitating mucosal wounding and inflammation, and further suggest that this may be mediated, in part, through control of RELMbeta production PMID: 21555532
    10. FIZZ2 is a T helper type (Th)2-associated multifunctional mediator with potentially important roles in the pathogenesis of fibrotic lung diseases. PMID: 21602491
    11. Secretion of RELMbeta is dramatically reduced in germ-free mice. Furthermore, introduction of germ-free mice into a conventional environment results in enhanced expression and robust secretion of RELMbeta within 48 hours. PMID: 14598255
    12. crystal structure reveals hexameric assemblies consisting of trimers linked to form hexamers through highly exposed disulfide bonds; structure suggests possible regulation through disulfide cleavage or by regulation during assembly PMID: 15155948
    13. intestinal goblet cell-derived RELMbeta may be a novel Th2 cytokine-induced immune-effector molecule in resistance to Gastrointestinal nematode infection PMID: 15340149
    14. Serum concentrations of RELMbeta and RELMgamma may be a novel intestinal-tract-mediating regulator of insulin sensitivity, possibly involved in insulin resistance induced by obesity and a high-fat diet PMID: 15834545
    15. increased expression of RELMbeta may be involved in the pathogenesis of glucose intolerance and hyperlipidemia in some insulin-resistant models PMID: 16243841
    16. model whereby the loss of epithelial barrier function by dextran sodium sulfate results in the activation of the innate mucosal response by RELMbeta located in the lumen PMID: 17024245
    17. RELM-beta is a Th2-associated cytokine with potent inflammatory and remodeling activity PMID: 17545488
    18. Insulin and TNFalpha as well as stearic acid, upregulated RELMbeta expression, while d-glucose downregulated RELMbeta PMID: 17936398
    19. RELMbeta is involved in the initiation of ileitis in SAMP1/Fc mice and may act through the induction of proinflammatory cytokines from resident immune cells within the mucosa. PMID: 17982092
    20. Goblet cell-macrophage cross-talk, mediated in part by RELMbeta, can promote adaptive CD4-positive T cell responses and chronic inflammation following intestinal helminth infection. PMID: 18802073
    21. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. PMID: 19995957

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Resistin/FIZZ family
  • 组织特异性：
    Strongly expressed in colon, and at lower levels in ileum. In colon, found throughout the crypt and surface epithelium and in goblet cells (at protein level). Specific to the gastrointestinal tract; not detected in other tissues tested.
  • 数据库链接：

    KEGG: mmu:57263

    STRING: 10090.ENSMUSP00000023328

    UniGene: Mm.21123