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  4. Recombinant Mouse Reticulon-4 receptor (Rtn4r)

Recombinant Mouse Reticulon-4 receptor (Rtn4r)

  • 中文名称：
    小鼠Rtn4r重组蛋白
  • 货号：
    CSB-YP860842MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rtn4r重组蛋白
  • 货号：
    CSB-EP860842MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rtn4r重组蛋白
  • 货号：
    CSB-EP860842MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rtn4r重组蛋白
  • 货号：
    CSB-BP860842MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rtn4r重组蛋白
  • 货号：
    CSB-MP860842MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rtn4r
  • Uniprot No.：
  • 别名：
    Rtn4r; Ngr1; Nogor; Reticulon-4 receptor; Nogo receptor; NgR; Nogo-66 receptor; Nogo66 receptor-1; NgR1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-447
  • 氨基酸序列
    CPGA CVCYNEPKVT TSCPQQGLQA VPTGIPASSQ RIFLHGNRIS HVPAASFQSC RNLTILWLHS NALARIDAAA FTGLTLLEQL DLSDNAQLHV VDPTTFHGLG HLHTLHLDRC GLRELGPGLF RGLAALQYLY LQDNNLQALP DNTFRDLGNL THLFLHGNRI PSVPEHAFRG LHSLDRLLLH QNHVARVHPH AFRDLGRLMT LYLFANNLSM LPAEVLMPLR SLQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCNLP QRLADRDLKR LAASDLEGCA VASGPFRPIQ TSQLTDEELL SLPKCCQPDA ADKASVLEPG RPASAGNALK GRVPPGDTPP GNGSGPRHIN DSPFGTLPSS AEPPLTALRP GGSEPPGLPT TGPRRRPGCS RKNRTRSHCR LGQAGSGASG TGDAEGS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Mediates axonal growth inhibition and plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development.
  • 基因功能参考文献：
    1. Nogo-A and NgR1 interactions may contribute to axonal branching in lateral olfactory tract development PMID: 28000762
    2. determine the expression pattern of NgR1 in the retina by co-labeling neurons with characterized markers of specific retinal neurons PMID: 29768445
    3. NgR1 ligand has a role in in oligodendrocyte progenitor cells fate in the context of a specific and common type of stroke PMID: 27956620
    4. The results of this study indicated that Nogo-66 signaling limits LTP via the ROCK2-Cofilin pathway to control the dynamics of the actin cytoskeleton. PMID: 27166169
    5. Results demonstrated that nogo receptor 1 (NgR1) expression is upregulated in the olfactory epithelium (OE) after injury, which suggests that NgR1 might be involved in the regeneration of the OE. PMID: 27138950
    6. Here we identify that the nogo-66 receptor 1 gene restricts an early and essential step in OD plasticity to the critical period. These findings link the emerging circuit-level description of OD plasticity to the genetic regulation of the critical period. Understanding how plasticity is confined to critical periods may provide clues how to better treat amblyopia. PMID: 27798181
    7. Nogo Receptor 1 limits ocular dominance plasticity but not turnover of axonal boutons in a model of amblyopia PMID: 25662716
    8. Results show that Nogo receptor 1 is a negative regulator of both structural synaptic plasticity and dendritic complexity in a brain region-specific manner, and highlight anterior cingulate cortex as a key area for memory-related plasticity. PMID: 26838771
    9. Rtn4r expression was reduced in spinal motor neurons from mice with a transgenic model of ALS. PMID: 26083872
    10. This study detected the expression of NgR1 in microglia during development and found that NgR1 protein expression increased significantly in microglia with aging. PMID: 26367446
    11. Ngr1 regulates tactile and motor task performance, it does not limit the rate of tactile or motor learning nor determine the low set point for synaptic turnover in adult sensory cortex. PMID: 25386856
    12. the Nogo/NgR signal might be involved in multiple processes in various inflammation-associated CNS diseases. PMID: 26472924
    13. Genetic ablation of NgR1 may lead to significant recovery in locomotor function after spinal cord injury PMID: 24594926
    14. NgR1 is required for efficient infection of primary cortical neurons by reovirus. PMID: 24922571
    15. NogoA receptors, NogoR1 and PirB, are expressed in the ventricular zone where neural stem cells reside. PMID: 24449409
    16. NgR1 functions with parvalbumin interneurons to limit plasticity of binocularity, but its expression is required more extensively to limit improvement of visual acuity following chronic deprivation. PMID: 25164659
    17. NgR1 has little if any effects on the repertoire of immune cells, their activation and trafficking to the CNS. PMID: 24339996
    18. ngr(-/-) animals show slower acquisition of a spatial learning and memory task PMID: 22260793
    19. These data suggest that NgR1 negatively influences plasticity and cognitive recovery after traumatic brain injury PMID: 22967270
    20. NgR1 determines the low set point for synaptic turnover in adult cerebral cortex PMID: 23473316
    21. findings reveal a new function for Nogo-A and NgR1 in the homeostatic regulation of the pace of neurogenesis and neuroblast migration. PMID: 23223298
    22. Nogo receptor and Nogo-A are actively regulated in experimental autoimmune encephalomyelitis (EAE) lesions, indicating a specific time window for localized axonal regeneration in the acute phase of EAE. PMID: 22964785
    23. The results of this study identify NgR1 and NgR3 as CSPG receptors, suggest that there is functional redundancy among CSPG receptors, and provide evidence for shared mechanisms of MAI and CSPG inhibition. PMID: 22406547
    24. Data show that genetic deletion of both receptors does not promote functional recovery during EAE and that NgR1 and NgR2-mediated signals play a minor role in the development of CNS inflammation. PMID: 22096481
    25. These findings suggest that the UA/EC region is a functional domain of LOTUS serving for an antagonistic action to NgR1. PMID: 22281491
    26. The results of this study suggested that NgR1, a receptor previously shown to restrict axon growth in the adult, also functions in the dendrite as a barrier that limits excitatory synapse number during brain development. PMID: 22325200
    27. These results indicate that a lack of NgR1/2 expression promotes the adhesion of DCs to myelin. PMID: 21906273
    28. Neuronal knockdown of MT3-matrix metalloproteinase resulted in the accumulation of NgR1 at the cell surface and reduced the accumulation of the NgR1 cleavage fragment in medium conditioned by cortical neurons PMID: 21768085
    29. found CRTAC1-B(LOTUS)is key molecule for lateral olfactory tract(LOT)formation; NgR1 is LOTUS-binding protein;LOTUS suppressed Nogo-NgR1 binding and Nogo-induced growth cone collapse;suggest endogenous antagonism of NgR1 by LOTUS crucial for LOT formation PMID: 21817055
    30. A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1. PMID: 21454605
    31. Thus either NgR gene deletion or exercise training benefits mice with mild cervical spinal injury PMID: 20809785
    32. NgR1 and paired Ig-like receptor-B (PirB) participate in ligand-dependent inhibition of synaptic plasticity in hippocampal slice cultures of adult mice. PMID: 20844138
    33. the structure of Nogo-66 requires interactions with a phosphocholine surface for protein folding at the membrane interface PMID: 20351248
    34. NgR and its ligand Nogo-A/B exist on mouse blastocysts and cultured ES cells, suggesting NgR might play a role in early embryo development. PMID: 19400741
    35. Nogo receptor 1 regulates formation of lasting memories. PMID: 19915139
    36. results suggest that Nogo may be involved in axon guidance by (i) preventing recrossing of axons across the midline through an upregulation of axonal NgR and (ii) partitioning axons in the ventral funiculus into longitudinal fascicles PMID: 19833111
    37. Nogo-66 retards neurite outgrowth and induces growth cone collapse by its interaction with NgR and as yet unidentified transmembrane coreceptors. PMID: 11891768
    38. Myelin-associated glycoprotein(MAG) binds directly, with high affinity, to NgR; MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury PMID: 12089450
    39. Localization of Nogo-66 receptor at sites of axon-myelin and synaptic contact PMID: 12097502
    40. Nogo-66-R mRNA expression in humans and mice was observed in neurons of the developing nervous system; expression was downregulated in the adult spinal cord of both species, and specific expression patterns were seen in the adult brain. PMID: 12378589
    41. The NgR antagonist extracellular peptide 1-40 promotes growth of corticospinal axons, serotonergic fibers and upregulation of the small proline-rich repeat protein 1A, and synapse reformation after spinal cord injury. PMID: 12764110
    42. Nogo receptor mRNA is expressed in the adult by both principal and local-circuit hippocampal neurons. PMID: 15121177
    43. These results are supportive of hypothesis that Nogo-NgR axis is major path for inhibition of spinal cord axonal regeneration and uphold promises of these neutralizing agents in clinical applications. (Review) PMID: 16092935
    44. mutations in the Nogo-66 receptor (NgR) affect cessation of ocular dominance plasticity; physiological NgR signaling from myelin-derived Nogo, MAG, and OMgp consolidates the neural circuitry established during experience-dependent plasticity PMID: 16195464
    45. The Nogo-66/NgR system is involved in regneeration of entorhinal/hippocamal axonal lesions in in vitro. PMID: 16407455
    46. role for Nogo receptors (NgRs) in macrophage efflux from sites of inflammation in peripheral nerve PMID: 17329206
    47. RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes PMID: 18043741
    48. Nogo receptor antagonizes p75NTR-dependent motor neuron death PMID: 18182498
    49. Expression patterns suggest an interaction of Nogo with its receptor in the mouse retinofugal pathway, which may be involved in guiding axons into the optic pathway and in governing the routing of axons in the optic chiasm. PMID: 18214994
    50. gangliosides inhibit neurite outgrowth by interacting with FRG motifs in the NgR1 and this interaction can also facilitate the binding of MAG to the NgR1 PMID: 18411262

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Cell projection, axon. Perikaryon.
  • 蛋白家族：
    Nogo receptor family
  • 组织特异性：
    Detected in embryonic hippocampus neurons. Detected in brain (at protein level). Detected in neurons in the neocortex, in hippocampus, dorsal thalamus, cerebellum granule cell layer and the mitral cell layer in the olfactory bulb. Detected in brain, dorsa
  • 数据库链接：

    KEGG: mmu:65079

    STRING: 10090.ENSMUSP00000062924

    UniGene: Mm.40149