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  4. Recombinant Mouse Retinoid-inducible serine carboxypeptidase (Scpep1)

Recombinant Mouse Retinoid-inducible serine carboxypeptidase (Scpep1)

  • 中文名称：
    小鼠Scpep1重组蛋白
  • 货号：
    CSB-YP849706MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Scpep1重组蛋白
  • 货号：
    CSB-EP849706MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Scpep1重组蛋白
  • 货号：
    CSB-EP849706MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Scpep1重组蛋白
  • 货号：
    CSB-BP849706MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Scpep1重组蛋白
  • 货号：
    CSB-MP849706MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Scpep1
  • Uniprot No.：
  • 别名：
    Scpep1; Risc; Retinoid-inducible serine carboxypeptidase; EC 3.4.16.-; Serine carboxypeptidase 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    29-452
  • 氨基酸序列
    ID WREPEGKEVW DYVTVRKDAH MFWWLYYATN PCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPLDTQLKP RNTTWLQWAS LLFVDNPVGT GFSYVNTTDA YAKDLDTVAS DMMVLLKSFF DCHKEFQTVP FYIFSESYGG KMAAGISVEL YKAVQQGTIK CNFSGVALGD SWISPVDSVL SWGPYLYSMS LLDNQGLAEV SDIAEQVLDA VNKGFYKEAT QLWGKAEMII EKNTDGVNFY NILTKSSPEK AMESSLEFLR SPLVRLCQRH VRHLQGDALS QLMNGPIKKK LKIIPEDISW GAQASYVFLS MEGDFMKPAI DVVDKLLAAG VNVTVYNGQL DLIVDTIGQE SWVQKLKWPQ LSKFNQLKWK ALYTDPKSSE TAAFVKSYEN LAFYWILKAG HMVPSDQGEM ALKMMKLVTK QE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in vascular wall and kidney homeostasis.
  • 基因功能参考文献：
    1. in normal tissues the tandem of serine carboxypeptidases, Scpep1 and CathA likely constitutes an important part of the physiological mechanism responsible for the balanced elimination of heightened levels of ET-1 that otherwise would accumulate in tissues and consequently contribute to development of the hyper-proliferative corneal dystrophy and abnormal skin thickening PMID: 28234994
    2. our results define the biological role of mammalian serine carboxypeptidase Scpep1 and suggest that Scpep1 and CathA together participate in the control of ET-1 regulation of vascular tone and hemodynamics PMID: 24586188
    3. A closer look to the mRNA transcriptome allowed s to identify upregulation of five miRISC genes, including Dgcr8 and Fmr1, and Ago2, which were later confirmed by real time PCR. PMID: 22310387
    4. Scpep1-deficient mice were viable and fertile, and did not exhibit either lysosomal storage or reduced lysosomal SC activity under any tested condition. PMID: 19187242
    5. SCPEP1 promotes smooth muscle cell proliferation and migration in a catalytic triad-dependent, cleavage-independent manner. PMID: 19574551

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S10 family
  • 数据库链接：

    KEGG: mmu:74617

    STRING: 10090.ENSMUSP00000000287

    UniGene: Mm.155708