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  4. Recombinant Mouse Retinol dehydrogenase 11 (Rdh11), partial

Recombinant Mouse Retinol dehydrogenase 11 (Rdh11), partial

  • 中文名称：
    小鼠Rdh11重组蛋白
  • 货号：
    CSB-YP874125MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rdh11重组蛋白
  • 货号：
    CSB-EP874125MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rdh11重组蛋白
  • 货号：
    CSB-EP874125MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rdh11重组蛋白
  • 货号：
    CSB-BP874125MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rdh11重组蛋白
  • 货号：
    CSB-MP874125MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rdh11
  • Uniprot No.：
  • 别名：
    Rdh11; Arsdr1; Mdt1; Psdr1; Retinol dehydrogenase 11; EC 1.1.1.300; Androgen-regulated short-chain dehydrogenase/reductase 1; Cell line MC/9.IL4-derived protein 1; M42C60; Prostate short-chain dehydrogenase/reductase 1; Retinal reductase 1; RalR1; Short-chain aldehyde dehydrogenase; SCALD
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol. Exhibits also reductive activity towards toxic lipid peroxidation products such as medium-chain aldehydes trans-2-nonenal, nonanal, and cis-6-nonenal. Has no dehydrogenase activity towards steroid. Seems to be required for homeostasis of retinol in liver and testis.
  • 基因功能参考文献：
    1. characterization of catalytic properties and tissue distribution PMID: 12807874
    2. RDH11 has a measurable role in regenerating the visual pigment by complementing RDH5 in retinal pigment epithelium. PMID: 15634683
    3. propose that mouse retinol dehydrogenase 11(mRDH11) disruption affects retinoid metabolism in photoreceptor inner segments and delays the kinetics of dark adaptation through modulation of calcium homeostasis PMID: 15790565
    4. RDH11 localizes to photoreceptor inner segments [review] PMID: 17249616
    5. Oxidative stress induced by exposure to constant bright light led to a rapid and significant decrease of RDH12 protein. The low and constant expression of RDH11 suggested a housekeeping function for this enzyme. PMID: 18326732

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 组织特异性：
    Expressed at high level in liver and testis. Expressed at lower levels in smooth muscle, thymus, submaxillary gland and epididymis. In testis, expression is restricted to pachytene spermatocytes. Also expressed in four layers of the retina, including the
  • 数据库链接：

    KEGG: mmu:17252

    STRING: 10090.ENSMUSP00000124066

    UniGene: Mm.291799