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  4. Recombinant Mouse Rho-related GTP-binding protein RhoJ (Rhoj)

Recombinant Mouse Rho-related GTP-binding protein RhoJ (Rhoj)

  • 中文名称：
    小鼠Rhoj重组蛋白
  • 货号：
    CSB-YP887658MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rhoj重组蛋白
  • 货号：
    CSB-EP887658MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rhoj重组蛋白
  • 货号：
    CSB-EP887658MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rhoj重组蛋白
  • 货号：
    CSB-BP887658MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rhoj重组蛋白
  • 货号：
    CSB-MP887658MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rhoj
  • Uniprot No.：
  • 别名：
    Rhoj; Arhj; Rhoi; Rhot; Tc10l; Tcl; Rho-related GTP-binding protein RhoJ; Tc10-like GTP-binding protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-211
  • 氨基酸序列
    MSCRERTDSS CGCNGHEENR ILKCVVVGDG AVGKTCLLMS YANDAFPEEY VPTVFDHYAV TVTVGGKQHL LGLYDTAGQE DYNQLRPLSY PNTDVFLICF SVVNPASYHN VQEEWVPELK DCMPHVPYVL IGTQIDLRDD PKTLARLLYM KEKPLTYEHG VKLAKAIGAQ CYLECSALTQ KGLKAVFDEA ILTIFHPKKK KKGCLGCHGC C
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plasma membrane-associated small GTPase specifically involved in angiogenesis. Required for endothelial cell migration during vascular development via its interaction with GLUL. Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration.
  • 基因功能参考文献：
    1. RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. Studies give insight into the molecular function of RhoJ in regulating cell motility. PMID: 24928894
    2. These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects. PMID: 24434213
    3. RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers. PMID: 21148427
    4. The results strongly suggest that TCL/TC10betaL regulates adipocyte differentiation by controlling mitotic clonal expansion and this regulatory effect is closely linked to C/EBPbeta and C/EBPdelta expression. PMID: 20190400
    5. cloning and functional characterization of related isoforms PMID: 11821390
    6. TCL/TC10betaL has a crucial role in the early stage of adipocyte differentiation, is probably linked to the PPARgamma pathway, and up-regulates epression of genes associated with adipogenesis. PMID: 12578843
    7. Insulin induces phosphatidylinositol 3-phosphate formation through TC10 activation. PMID: 12912916

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 组织特异性：
    Highly expressed in heart with moderate levels in lung and liver. Very low levels detected in brain, spleen, skeletal muscle, kidney and testis.
  • 数据库链接：

    KEGG: mmu:80837

    STRING: 10090.ENSMUSP00000059498

    UniGene: Mm.27467