Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Ribosomal protein S6 kinase alpha-2 (Rps6ka2)

Recombinant Mouse Ribosomal protein S6 kinase alpha-2 (Rps6ka2)

  • 中文名称：
    小鼠Rps6ka2重组蛋白
  • 货号：
    CSB-YP896249MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rps6ka2重组蛋白
  • 货号：
    CSB-EP896249MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rps6ka2重组蛋白
  • 货号：
    CSB-EP896249MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rps6ka2重组蛋白
  • 货号：
    CSB-BP896249MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rps6ka2重组蛋白
  • 货号：
    CSB-MP896249MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rps6ka2; Mapkapk1c; Rsk3Ribosomal protein S6 kinase alpha-2; S6K-alpha-2; EC 2.7.11.1; 90 kDa ribosomal protein S6 kinase 2; p90-RSK 2; p90RSK2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; Protein-tyrosine kinase Mpk-9; Ribosomal S6 kinase 3; RSK-3; pp90RSK3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-733
  • 氨基酸序列
    MELSMKKFTV RRFFSVYLRK KSRSKSSSLS RLEEEGIVKE IDISNHVKEG FEKADPSQFE LLKVLGQGSY GKVFLVRKVT GSDAGQLYAM KVLKKATLKV RDRVRSKMER DILAEVNHPF IVKLHYAFQT EGKLYLILDF LRGGDLFTRL SKEVMFTEED VKFYLAELAL ALDHLHGLGI IYRDLKPENI LLDEEGHIKI TDFGLSKEAT DHDKRAYSFC GTIEYMAPEV VNRRGHTQSA DWWSFGVLMF EMLTGSLPFQ GKDRKETMAL ILKAKLGMPQ FLSAEAQSLL RALFKRNPCN RLGAGVDGVE EIKRHPFFVT IDWNKLYRKE IKPPFKPAVG RPEDTFHFDP EFTARTPTDS PGVPPSANAH HLFRGFSFVA SSLVQEPSQQ DVPKAPIHPI VQQLHGNNIH FTDGYEIKED IGVGSYSVCK RCVHKATDAE YAVKIIDKSK RDPSEEIEIL LRYGQHPNII TLKDVYDDGK YVYLVMELMR GGELLDRILR QRCFSEREAS DVLYTIARTM DYLHSQGVVH RDLKPSNILY MDESGNPESI RICDFGFAKQ LRAENGLLMT PCYTANFVAP EVLKRQGYDA ACDVWSLGIL LYTMLAGFTP FANGPDDTPE EILARIGSGK YALSGGNWDS ISDAAKDVVS KMLHVDPQQR LTAVQVLKHP WIVNREYLSQ NQLSRQDVHL VKGAMAATYF ALNRTPQAPR LEPVLSSSLA QRRGMKRLTS TRL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
  • 基因功能参考文献：
    1. We confirmed that Raf1(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 was increased in Raf1(L613V) mice. Constitutive RSK3 gene deletion prevented the Raf1(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice. PMID: 26940993
    2. RSK3 is required for the induction of interstitial cardiac fibrosis in alpha-tropomyosin Glu180Gly transgenic mice. PMID: 23913705
    3. Anchored RSK3 transduces signals that modulate pathologic myocyte growth in cardiac hypertrophy. PMID: 22997248
    4. p90RSK2 is dispensable for BCR-Abl-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in Flt3-internal tandem duplication-induced hematopoietic transformation. PMID: 21527514
    5. activation and translocation of p90 ribosomal S6 protein kinase requires RANTES-mediated chemokine transcription in astrocytes PMID: 11893739
    6. p90Rsk2 and Emi1 functionally interact during oocyte maturation PMID: 15526037
    7. inhibition of p90RSK prevented H2O2-mediated cTnI (Ser(23/24)) phosphorylation but not ERK1/2 and PKCalpha/betaII activation PMID: 15840586
    8. p90RSK is a novel regulator of cardiac NHE1 activity by phosphorylating NHE1 serine 703 and a new pathological mediator of I/R injury in the heart PMID: 16717153
    9. there is a functional link between S6K1 II and CK2 signaling, which involves the regulation of S6K1 II nuclear export by CK2-mediated phosphorylation of Ser-17 PMID: 16895915
    10. RSK2 is a key regulator for cell transformation induced by tumor promoters such as EGF and TPA. PMID: 17804722
    11. These data indicate that Ribosomal s6 kinase 2 negatively regulates axon elongation via the MAPK pathway. PMID: 19555761

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
  • 数据库链接：

    KEGG: mmu:20112

    STRING: 10090.ENSMUSP00000024575

    UniGene: Mm.268383