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  4. Recombinant Mouse SH3 domain-binding protein 1 (Sh3bp1)

Recombinant Mouse SH3 domain-binding protein 1 (Sh3bp1)

  • 中文名称：
    小鼠Sh3bp1重组蛋白
  • 货号：
    CSB-YP021223MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sh3bp1重组蛋白
  • 货号：
    CSB-EP021223MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sh3bp1重组蛋白
  • 货号：
    CSB-EP021223MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sh3bp1重组蛋白
  • 货号：
    CSB-BP021223MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sh3bp1重组蛋白
  • 货号：
    CSB-MP021223MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sh3bp1
  • Uniprot No.：
  • 别名：
    Sh3bp1; 3bp1SH3 domain-binding protein 1; 3BP-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-601
  • 氨基酸序列
    MAESFKELDP DSSMGKALEM TCAIQNQLAR ILAEFEMTLE RDVLQPLSRL SEEELPAILK HKKSLQKLVS DWNTLKSRLS QAAKNSGSNQ GLGGASGSHT HTTTANKVEM LKEEEEELKK KVEQCKDEYL ADLYHFSTKE DSYANYFIHL LEIQADYHRK SLTSLDTALA ELRDNHSQAD HSPLTTAAPF SRVYGVSLRT HLQDLGRDIA LPIEACVLLL LSEGMQEEEG LFRLAAGASV LKRLKQTMAS DPHSLEEFCS DPHAVAGALK SYLRELPEPL MTSDLYDDWM RAASLKEPGA RLEALHDVCS RLPQENFNNL RYLMKFLALL AEEQDVNKMT PSNIAIVLGP NLLWPPEKEG DQAQLDAASV SSIQVVGVVE ALIQNADTLF PGDINFNVSG IFPGLAPQEK VSSQQVSEEL PPVTVPAPAT TPAPTPAPAS MAVRERTEAD LPKPTSPKVS RNPTETAASA EDMTRKTKRP APARPTMPPP QPSSTRSSPP APSLPPGSVS PGTPQALPRR LVGTSLRAPT MPPPLPPVPP QPARRQSRRL PASPVISNMP AQVDQGVATE DRGGPEAVGG HPPPPALPPQ PRPRGLISET E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells.
  • 亚细胞定位：
    Cell projection. Cell junction, tight junction. Cell junction, adherens junction. Cell projection, phagocytic cup. Nucleus. Cytoplasm, cytosol.
  • 组织特异性：
    Expressed in all tissues examined. Highest levels found in spleen and brain, lowest in heart and liver.
  • 数据库链接：

    KEGG: mmu:20401

    STRING: 10090.ENSMUSP00000052181

    UniGene: Mm.4462