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  4. Recombinant Mouse SHC-transforming protein 3 (Shc3)

Recombinant Mouse SHC-transforming protein 3 (Shc3)

  • 中文名称：
    小鼠Shc3重组蛋白
  • 货号：
    CSB-YP730724MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Shc3重组蛋白
  • 货号：
    CSB-EP730724MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Shc3重组蛋白
  • 货号：
    CSB-EP730724MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Shc3重组蛋白
  • 货号：
    CSB-BP730724MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Shc3重组蛋白
  • 货号：
    CSB-MP730724MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Shc3; Nshc; ShcC; SHC-transforming protein 3; Neuronal Shc; N-Shc; SHC-transforming protein C; Src homology 2 domain-containing-transforming protein C3; SH2 domain protein C3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-474
  • 氨基酸序列
    MSATRKSRAG DEPLPRPPRG APHTSDQVLG PGVTYVVKYL GCIEVLRSMR SLDFSTRTQV TREAISRVCE AVPGAKGALK KRKPPSKMLS SILGKSNLQF AGMSISLTIS TASLNLRTPD SKQIIANHHM RSISFASGGD PDTTDYVAYV AKDPVNRRAC HILECCDGLA QDVIGSIGQA FELRFKQYLQ CPSKVPALQD RMQSLDEPWT EEEGDGPDHP YYNSVPTKMP PPGGFLDARL KGRPHAPEAA QFAGKEQTYY QGRHLGDTFG EDWQRAPTRQ GSLDIYSTAE GKTHMVPVGE TPTYVNTQPV PPQVWPAATS STESSPRKDL FDMKPFEDAL RNQPLGPMLS KAASVECISP VTPRAPDARM LEELNAEPWY QGEMSRKEAE ALLREDGDFL VRKSTTNPGS FVLTGMHNGQ AKHLLLVDPE GTIRTKDRVF DSISHLINYH LESSLPIVSA GSELCLQQPV ERKP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
  • 基因功能参考文献：
    1. The results provide evidence that Rai/ShcC plays opposite roles in Th17 cell differentiation and astrocyte activation PMID: 27288534
    2. Deficit of p66ShcA restores redox-sensitive stress response program in cisplatin-induced acute kidney injury. PMID: 23506954
    3. Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. PMID: 22311806
    4. Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 to the phosphorylated subunit of the TCR/CD3 complex. PMID: 22242145
    5. binds the Trk receptors in a phosphotyrosine-dependent manner via their N-terminal phosphotyrosine binding domain PMID: 12006576
    6. Rai has a functional neuroprotective role in brain injury, with possible implications in the treatment of stroke PMID: 15494442
    7. ShcC mediates TrkB-Ras/MAPK signaling & regulates NMDA receptor function in the hippocampus via interaction with phosphotyrosines on the receptor subunits. It serves as a modulator of hippocampal synaptic plasticity underlying learning & memory. PMID: 15716419
    8. ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma cells PMID: 15735675
    9. Expressed in T and B cells; loss of Rai results in breaking of immunological tolerance and development of systemic autoimmunity. PMID: 19109161
    10. study reports co-localization of adaptor proteins nShc & Grb10, with Kv1.3 channel in the olfactory bulb neural lamina; BDNF-induced current suppression of the Kv1.3 channel was prevented by both nShc and Grb10 PMID: 19166614

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  • 组织特异性：
    Predominantly expressed in the adult brain.
  • 数据库链接：

    KEGG: mmu:20418

    STRING: 10090.ENSMUSP00000021898

    UniGene: Mm.131870