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  4. Recombinant Mouse Secretogranin-3 (Scg3)

Recombinant Mouse Secretogranin-3 (Scg3)

  • 中文名称：
    小鼠Scg3重组蛋白
  • 货号：
    CSB-YP020809MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Scg3重组蛋白
  • 货号：
    CSB-EP020809MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Scg3重组蛋白
  • 货号：
    CSB-EP020809MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Scg3重组蛋白
  • 货号：
    CSB-BP020809MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Scg3重组蛋白
  • 货号：
    CSB-MP020809MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Scg3
  • Uniprot No.：
  • 别名：
    Scg3; Secretogranin-3; Secretogranin III; SgIII
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-471
  • 氨基酸序列
    FPKPEGSQ DKSLHNRELS AERPLNEQIA EAEADKIKKA FPSESKPSES NYSSVDNLNL LRAITEKETV EKERQSIRSP PFDNQLNVED ADSTKNRKLI DEYDSTKSGL DHKFQDDPDG LHQLDGTPLT AEDIVHKIAT RIYEENDRGV FDKIVSKLLN LGLITESQAH TLEDEVAEAL QKLISKEANN YEETLDKPTS RTENQDGKIP EKVTPVAAVQ DGFTNRENDE TVSNTLTLSN GLERRTNPHR EDDFEELQYF PNFYALLTSI DSEKEAKEKE TLITIMKTLI DFVKMMVKYG TISPEEGVSY LENLDETIAL QTKNKLEKNT TDSKSKLFPA PPEKSQEETD STKEEAAKME KEYGSLKDST KDDNSNLGGK TDEATGKTEA YLEAIRKNIE WLKKHNKKGN KEDYDLSKMR DFINQQADAY VEKGILDKEE ANAIKRIYSS L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway.
  • 基因功能参考文献：
    1. This review summarizes our current knowledge of Scg3 as a regulatory protein of secretory granules, highlights its new role as a highly disease-selective angiogenic factor, and envisions Scg3 inhibitors as "selective angiogenesis blockers" for targeted therapy of diabetic retinopathy.[ review] PMID: 28856381
    2. we show by RNA silencing that CPE and SgIII play a synergistic role in the trafficking of POMC to granules of the regulated secretory pathway in AtT20 cells PMID: 26646096
    3. SgIII knockdown impairs intracellular retention of chromogranin A and proopiomelanocortin in AtT-20 cells. PMID: 23171199
    4. The robust expression of SgIII in astrocytes and its regulation in the injured brain suggest both intracellular and extracellular roles for this glial granin in the physiology and repair/damage of neuronal circuits. PMID: 19892786
    5. SgIII directly binds to cholesterol components of the secretory granule membrane and targets chromogranin A to secretory granules in pituitary and pancreatic endocrine cells PMID: 14597614
    6. SgIII and CPE form the separate functional sorting complex by anchoring to cholesterol-rich SG membranes, and POMC-derived peptides are transferred from CPE to SgIII, and subsequently to CgA. PMID: 16219686

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted.
  • 组织特异性：
    Expressed in various brain areas, with highest levels in the arcuate nucleus and the lateral hypothalamic area, as well as the paraventricular nucleus and the ventromedial hypothalamus (at protein level).
  • 数据库链接：

    KEGG: mmu:20255

    STRING: 10090.ENSMUSP00000034699

    UniGene: Mm.2386