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  4. Recombinant Mouse Selenoprotein W (Sepw1)

Recombinant Mouse Selenoprotein W (Sepw1)

  • 中文名称：
    小鼠Selenow重组蛋白
  • 货号：
    CSB-YP021034MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Selenow重组蛋白
  • 货号：
    CSB-EP021034MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Selenow重组蛋白
  • 货号：
    CSB-EP021034MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Selenow重组蛋白
  • 货号：
    CSB-BP021034MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Selenow重组蛋白
  • 货号：
    CSB-MP021034MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Selenow
  • Uniprot No.：
  • 别名：
    Selenow; Selw; Sepw1; Selenoprotein W; SelW
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-88
  • 氨基酸序列
    ALAVRVVYC GAUGYKPKYL QLKEKLEHEF PGCLDICGEG TPQVTGFFEV TVAGKLVHSK KRGDGYVDTE SKFRKLVTAI KAALAQCQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency.
  • 基因功能参考文献：
    1. SelW enhances myoblast differentiation by inhibiting TAZ binding to 14-3-3. PMID: 24726955
    2. SelW gene was activated by the binding of MyoD to a specific E-box during early skeletal muscle differentiation. PMID: 20956524
    3. The main function of SelW in muscle cells is not in the antioxidative system. PMID: 20367607
    4. Data show that the loss of SelT elevates expression of another selenoprotein, selenoprotein W, suggesting that SepW1 may functionally compensate for SelT. PMID: 19935881
    5. Selenoprotein W is involved in muscle growth and differentiation by protecting the developing myoblasts from oxidative stress PMID: 16876868
    6. increased in mouse brains of postnatal day 8 and 20 relative to embryonic day 15; siRNA-transfected neurons are more sensitive to the oxidative stress-induced apoptosis PMID: 19466610

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    SelWTH family, Selenoprotein W subfamily
  • 组织特异性：
    In the embryo, expressed in the developing nervous system and in mesoderm-derived tissues such as heart and limbs. In the adult, predominantly expressed in brain, skeletal muscle and heart.
  • 数据库链接：

    KEGG: mmu:20364

    STRING: 10090.ENSMUSP00000038943

    UniGene: Mm.42829