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  4. Recombinant Mouse Semaphorin-6A (Sema6a), partial

Recombinant Mouse Semaphorin-6A (Sema6a), partial

  • 中文名称：
    小鼠Sema6a重组蛋白
  • 货号：
    CSB-YP020996MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sema6a重组蛋白
  • 货号：
    CSB-EP020996MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sema6a重组蛋白
  • 货号：
    CSB-EP020996MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sema6a重组蛋白
  • 货号：
    CSB-BP020996MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sema6a重组蛋白
  • 货号：
    CSB-MP020996MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sema6a
  • Uniprot No.：
  • 别名：
    Sema6a; Semaq; Semaphorin-6A; Semaphorin Q; Sema Q; Semaphorin VIA; Sema VIA; Semaphorin-6A-1; SEMA6A-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
  • 基因功能参考文献：
    1. These findings implicate Semaphorin-6A - Plexin-A2/Plexin-A4 interactions in dorsal lateral geniculate nucleus axon guidance and in the spatiotemporal organization of guidepost cell populations in the mammalian subpallium. PMID: 28438183
    2. Shear stress-regulated miR-27b promotes the interaction of endothelial cells with pericytes, partly by repressing SEMA6A and SEMA6D. PMID: 28453731
    3. mutations in Sema6A, and/or possibly interacting genes, may result in dysfunction at the level of neuronal networks with associated behavioural phenotypes of relevance to neuropsychiatric disorders PMID: 28109776
    4. The experiments reveal the complex nature of Sema6A biochemical functions and the molecular logic of the context-dependent interactions between Sema6A and PlxnA2. PMID: 27392094
    5. Using time-lapse videomicroscopy we provide evidence that Sema6A/PlexinA2 signaling participates to interkinetic nuclear migration of retinal progenitor cell PMID: 27301906
    6. findings reveal a unique function of Nrf2 in reprogramming ischemic tissue toward neurovascular repair via Sema6A regulation, providing a potential therapeutic strategy for ischemic retinal and CNS diseases PMID: 26621751
    7. Tangential migration is selectively altered in cerebellar neurons of Sema6A knockouts. PMID: 25284064
    8. semaphorin 6A is expressed in On starburst amacrine cell. PMID: 24179230
    9. Sema6A expressed in oligodendrocyte precursor cells is involved in their autonomous migration through ligand-receptor interaction with Plexin-A4 expressed in surrounding cells. PMID: 23376059
    10. The results of this study suggested that Sema6A might have a role in myelination by controlling oligodendrocyte differentiation. PMID: 22777942
    11. Adult Sema6A-null mice exhibit reduced tumor, matrigel, and choroidal angiogenesis compared with controls. Here we show that it also regulates vascular development and adult angiogenesis. PMID: 23007403
    12. null mutations in Sema6A or PlexinA4 (PlexA4) exhibit a pronounced defect in OPL stratification of horizontal cell axons without any apparent deficits in bipolar cell dendrite or photoreceptor axon targeting. PMID: 22593055
    13. Mice with mutations in Sema6A or the interacting genes may thus represent a highly informative model for how neurodevelopmental defects can lead to anatomical dysconnectivity. PMID: 22132072
    14. the transmembrane semaphorin Sema6A signals through its receptor PlexinA4 (PlexA4) to control lamina-specific neuronal stratification in the mouse retina PMID: 21270798
    15. crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1(1-2)-SEMA4D(ecto) and murine PlxnA2(1-4)-Sema6A(ecto)), plus unliganded structures of PlxnA2(1-4) and Sema6A(ecto) PMID: 20877282
    16. regulates lamina-restricted projection of hippocampal mossy fiber.(review) PMID: 21089322
    17. crystal structures of the semaphorin 6A (Sema6A) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states PMID: 20881961
    18. suggesting that a Sema6A-Plexin-A4 cis interaction serves as an inhibitory mechanism. PMID: 20606624
    19. During cerebellum development, Sema6A is selectively expressed by postmitotic granule cells during their tangential migration in the deep external granule cell layer, but not during their radial migration. PMID: 16205717
    20. Centrosome-nucleus coupling and coordinated motility were strongly perturbed in Sema6a-deficient granule cells suggesting that semaphorin-plexin signaling modulates cell migration by controlling centrosome positioning. PMID: 18327254
    21. Data show that Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points. PMID: 19063725

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Semaphorin family
  • 组织特异性：
    Particularly high levels in spinal cord, cerebellum, metencephalon, superior and inferior colliculus, diencephalon, olfactory bulb and eye.
  • 数据库链接：

    KEGG: mmu:20358

    STRING: 10090.ENSMUSP00000019791

    UniGene: Mm.40909