Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Serum amyloid P-component (Apcs)

Recombinant Mouse Serum amyloid P-component (Apcs)

  • 中文名称：
    Recombinant Mouse Serum amyloid P-component(Apcs),Yeast
  • 货号：
    CSB-YP001898MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Serum amyloid P-component(Apcs),Yeast
  • 货号：
    CSB-EP001898MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Serum amyloid P-component(Apcs),Yeast
  • 货号：
    CSB-EP001898MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Serum amyloid P-component(Apcs),Yeast
  • 货号：
    CSB-BP001898MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Serum amyloid P-component(Apcs),Yeast
  • 货号：
    CSB-MP001898MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Apcs
  • Uniprot No.：
  • 别名：
    Apcs; Ptx2; Sap; Serum amyloid P-component; SAP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    21-224
  • 氨基酸序列
    QTDLKRKVFV FPRESETDHV KLIPHLEKPL QNFTLCFRTY SDLSRSQSLF SYSVKGRDNE LLIYKEKVGE YSLYIGQSKV TVRGMEEYLS PVHLCTTWES SSGIVEFWVN GKPWVKKSLQ REYTVKAPPS IVLGQEQDNY GGGFQRSQSF VGEFSDLYMW DYVLTPQDIL FVYRDSPVNP NILNWQALNY EINGYVVIRP RVWD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. SAP deficiency mitigated foam cell formation and atherosclerotic development in apoE(-/-) mice, due to reduction in macrophages recruitment, polarization and pro-inflammatory cytokines PMID: 26649902
    2. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. PMID: 26106150
    3. observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation PMID: 22493081
    4. Bglu3 is confirmed to be a locus affecting diabetes susceptibility, and Apcs is a probable candidate gene. PMID: 22274563
    5. binding of SAP to ALD-DNA could switch macrophage phenotypic polarization from proinflammatory M2b to anti-inflammatory M2a via PI3K/Akt-ERK signaling activation, thus exerting protective and therapeutic interventions on murine lupus nephritis PMID: 21753147
    6. SAP has an effect on macrophages in fibrotic lung disease PMID: 20300636
    7. sFRP4 negatively regulates bone formation without disrupting phosphorus homeostasis. PMID: 20472109
    8. Serum amyloid P is elevated in the urine and kidneys of mice during anti-glomerular basement membrane disease, as well as in mice with spontaneously arising lupus nephritis. PMID: 20065116
    9. Binding of mouse and human SAP to immobilized influenza virus was compared. Mouse SAP bound much less avidly than human SAP.mouse SAP apparently plays no significant role during infection of mice with influenza virus. PMID: 11984001
    10. Targeted pharmacological depletion of serum amyloid P component for treatment of amyloidosis PMID: 12015594
    11. during murine tuberculosis (TB) SAP levels were increased; purified mouse SAP inhibited the intra-alveolar macrophage M. tuberculosis growth, in vitro; SAP may thus contribute both to the pathogenesis and pulmonary innate immunity in TB PMID: 16298151
    12. SAP may modulate the inflammatory response to amyloid fibrils in atherosclerosis PMID: 17630380
    13. These results show a novel and physiologically significant role for SAP for complement-mediated immunity against an important bacterial pathogen, and provide further evidence for the importance of the classical complement pathway for innate immunity. PMID: 17845072
    14. Cells sensing they are inflicted with mortal injury can turn on molecular programs insuring not only that they die by apoptosis but also that once they are dead their elimination is (facilitated by SAP) swift and efficient. PMID: 18046483

    显示更多

    收起更多

  • 相关疾病：
    SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Pentraxin family
  • 数据库链接：

    KEGG: mmu:20219

    STRING: 10090.ENSMUSP00000027824

    UniGene: Mm.330510