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  4. Recombinant Mouse Serum response factor-binding protein 1 (Srfbp1)

Recombinant Mouse Serum response factor-binding protein 1 (Srfbp1)

  • 中文名称：
    小鼠Srfbp1重组蛋白
  • 货号：
    CSB-YP863469MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Srfbp1重组蛋白
  • 货号：
    CSB-EP863469MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Srfbp1重组蛋白
  • 货号：
    CSB-EP863469MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Srfbp1重组蛋白
  • 货号：
    CSB-BP863469MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Srfbp1重组蛋白
  • 货号：
    CSB-MP863469MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Srfbp1
  • Uniprot No.：
  • 别名：
    Srfbp1; Serum response factor-binding protein 1; SRF-dependent transcription regulation-associated protein; p49/STRAP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-441
  • 氨基酸序列
    MAADPLPPSA MVQPGTLNLN NEVVKMRKEV KRIRVLVIRK LVRSVGRLKS KKGTEDALLK NQRRAQRLLE EIHAMKELKP DVVTKSALSD DINFEKTCKK PDSTATDRAV ARLAGHPLLK KKIDVLKDAV QAFKDARQSA PAAESSESTS GEGRCKDIAR SKDDARESQH PERTVVREQK AKDTNTAAKN AASGSKEKLA KTEQAPRAGT TPGSQGRPSG KGAGVNSEHQ GAPAPGDSNQ GKASTKTPED SVCEPANNGV SEEEESEGEK EYFDDSTEER FYKQSSASED SDSGDDFFIG KVRRTRKKES GVHSSAKELK PLPKVPSKTS TLETPWDVRN DKHRPIPEAR KFESVFFHSL AGPKSSRRDP REQAPKNKAP DFPENEPPVK KQFTKSAYRG FESVKQTMQA PLHPSWEASR RRKEQQSKIA VFQGKKITFD D
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.
  • 基因功能参考文献：
    1. P49/STRAP expression was increased in the old versus young adult mouse hearts and also increased with advancing population doubling levels in cultured human umbilical vein endothelial cells. The increased expression of p49/STRAP in late life may alter the status of histone acetylation and impact mitochondrial dynamics and thereby reduce mitochondrial function and cardiac performance during mammalian senescence. PMID: 27337995
    2. Overexpression of p49/STRAP reduced actin content in cultured cells and resulted in smaller cell size versus control cells. PMID: 25183317
    3. p49/STRAP may be an important SRF cofactor in the transcriptional regulation of mammalian cardiac muscle genes throughout the life span PMID: 15492011
    4. 49-kDa protein (p49/STRAP) specifically interacts with an acidic amino acid motif (Q7IGSEDG) in the N-terminus of GLUT4. PMID: 16647043
  • 亚细胞定位：
    Cytoplasm, perinuclear region.
  • 组织特异性：
    Highly expressed in heart, skeletal muscle, liver, kidney, testis and brain. Also expressed in white adipose tissue. Expression is up-regulated in cardiomyopathic heart.
  • 数据库链接：

    KEGG: mmu:67222

    STRING: 10090.ENSMUSP00000025406

    UniGene: Mm.100617